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Distinct mechanisms eliminate mother and daughter centrioles in meiosis of star...
Borrego-Pinto, Joana; Somogyi, Kálmán; Karreman, Matthia A.; König, Julia; Müller-Reichert, Thomas; Bettencourt-Dias, Mónica; Gönczy, PierreCentriole elimination is an essential process that occurs in female meiosis of metazoa to reset centriole number in the zygote at fertilization. How centrioles are eliminated remains poorly understood. Here we visualize the entire elimination process live in starfish oocytes. Using specific fluorescent markers, we demonstrate that the two older, mother centrioles are selectively removed from the oocyte by extru...
Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole ...
Cunha-Ferreira, Inês; Bento, Inês; Pimenta-Marques, Ana; Jana, Swadhin Chandra; Lince-Faria, Mariana; Duarte, Paulo; Borrego-Pinto, JoanaPolo-like kinase 4 (PLK4) is a major player in centriole biogenesis: in its absence centrioles fail to form, while in excess leads to centriole amplification. The SCF-Slimb/βTrCP-E3 ubiquitin ligase controls PLK4 levels through recognition of a conserved phosphodegron. SCF-Slimb/βTrCP substrate binding and targeting for degradation is normally regulated by phosphorylation cascades, controlling complex processes...