8 documents found, page 1 of 1
Akkermansia muciniphila and Parabacteroides distasonis synergistically protect ...
Gaifem, Joana; Mendes-Frias, Ana; Wolter, Mathis; Steimle, Alex; Garzón, Maria Jose; Ubeda, Carles; Nobre, Clarisse; González, Abigail; Pinho, Salomé S.The contribution of the gut microbiome to the balance between homeostasis and inflammation is widely known. Nevertheless, the etiology of inflammatory bowel disease, which is known to be influenced by genetics, immune response, and environmental cues, remains unclear. Unlocking novel players involved in the dictation of a protective gut, namely, in the microbiota component, is therefore crucial to develop novel...
Functional genetic variants in ATG10 are associated with acute myeloid leukemia
Castro, Isabel; Marques, Maria Belém Sousa Sampaio; Areias, Anabela Cepa; Sousa, Hugo; Fernandes, Ângela; Sanchez-Maldonado, José ManuelAcute myeloid leukemia (AML) is the most common acute leukemia, characterized by a heterogeneous genetic landscape contributing, among others, to the occurrence of metabolic reprogramming. Autophagy, a key player on metabolism, plays an essential role in AML. Here, we examined the association of three potentially functional genetic polymorphisms in the <i>ATG10</i> gene, central for the autophagosome formation....
Genetic defects in fungal recognition and susceptibility to invasive pulmonary ...
Cunha, Cristina Amorim; Carvalho, AgostinhoThe interindividual variability in the onset and clinical course of invasive pulmonary aspergillosis (IPA) raises fundamental questions about its actual pathogenesis. Clinical and epidemiological studies have reported only a few examples of monogenic defects, however an expanding number of common polymorphisms associated with IPA has been identified. Understanding how genetic variation regulates the immune resp...
The cell biology of the Trichosporon-Host interaction
Oliveira, Cláudio Duarte; Rodrigues, Fernando José dos Santos; Gonçalves, Samuel M.; Goldman, Gustavo H.; Carvalho, Agostinho Albérico RodriguesFungi of the genus Trichosporon are increasingly recognized as causative agents of superficial and invasive fungal disease in humans. Although most species are considered commensals of the human skin and gastrointestinal tract, these basidiomycetes are an increasing cause of fungal disease among immunocompromised hosts, such as hematological patients and solid organ transplant recipients. The initiation of comm...
The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungal d...
Gonçalves, Samuel Martins; Lagrou, Katrien; Oliveira, Cláudio Manuel Duarte; Maertens, Johan A.; Cunha, Cristina Amorim; Carvalho, AgostinhoFilamentous fungi of the genus Aspergillus are responsible for several superficial and invasive infections and allergic syndromes. The risk of infection and its clinical outcome vary significantly even among patients with similar predisposing clinical factors and pathogen exposure. There is increasing evidence that the individual microbiome supervises the outcome of the host-fungus interaction by influencing me...
Host-derived biomarkers for risk assessment of invasive fungal diseases
Cunha, Cristina Amorim; Gonçalves, Samuel M.; Carvalho, Agostinho Albérico RodriguesHost-Derived Biomarkers for Risk Assessment of Invasive Fungal Diseases; Invasive fungal diseases are major complications associated with the treatment of hematologic malignancies. The integration of host-derived biomarkers into clinical processes to predict the risk and progression of fungal disease is a promising approach in immunocompromised patients. Recent insights into human antifungal immunity have highl...
The soluble pattern recognition receptor PTX3 links humoral innate and adaptive...
Chorny, Alejo; Casas‑Recasens, Sandra; Sintes, Jordi; Shan, Meimei; Polentarutti, Nadia; García‑Escudero, Ramón; Cunha, Cristina AmorimPentraxin 3 (PTX3) is a fluid-phase pattern recognition receptor of the humoral innate immune system with ancestral antibody-like properties but unknown antibody-inducing function. In this study, we found binding of PTX3 to splenic marginal zone (MZ) B cells, an innate-like subset of antibody-producing lymphocytes strategically positioned at the interface between the circulation and the adaptive immune system. ...
Polymorphisms in host immunity modulating genes and risk of invasive aspergillo...
Lupiañez, C. B.; Canet, L. M.; Carvalho, Agostinho Albérico Rodrigues de; Alcazar-Fuolie, L.; Springer, J.; Lacknerg, M.; Segura-Catena, J.; Comino, A.Recent studies suggest that immune-modulating single nucleotide polymorphisms (SNPs) influence the risk of developing cancer-related infections. Here, we evaluated whether 36 SNPs within 14 immune-related genes are associated with the risk of Invasive Aspergillosis (IA) and whether genotyping of these variants might improve disease risk prediction. We conducted a case-control association study of 781 immunocomp...