9 documents found, page 1 of 1

TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related int...

Made available in DSpace on 2022-05-01T07:58:47Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-10-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; Background and purpose: Severe diarrhoea, a common gastrointestinal manifestation of anticanc...

Dysregulation of interferon regulatory genes reinforces the concept of chronic ...

Severely impaired terminal erythroid differentiation as an independent prognost...

Anemia is the defining feature in most patients with myelodysplastic syndromes (MDS), yet defects in erythropoiesis have not been well characterized. We examined freshly obtained bone marrow (BM) samples for stage-specific abnormalities during terminal erythroid differentiation (TED) from 221 samples (MDS, n = 205 from 113 unique patients; normal, n = 16) by measuring the surface expression of glycophorin A, ba...

Interleukin-8 and nuclear factor kappa B are increased and positively correlate...

The pathogenesis of myelodysplastic syndromes (MDS) is complex and depends on the interaction between aberrant hematopoietic cells and their microenvironment, probably including aberrations in cytokines and their signaling pathways. To evaluate interleukin-8 (IL-8) plasma levels and nuclear factor kappa B (NF-kB) in patients with MDS and to test possible correlation between IL-8 and NFKb, a total of 45 individu...

Myelodysplastic syndrome patients present more severe respiratory muscle impair...

The ageing process is associated with gradual decline in respiratory system performance. Anemia is highly prevalent among older adults and usually associated with adverse outcomes. Myelodysplastic syndromes (MDS) are a heterogeneous group of hematologic malignancies with increasing incidence with age and characterized by anemia and other cytopenias. The main objectives of this study were to evaluate respiratory...

New polymorphisms of Xeroderma Pigmentosum DNA repair genes in myelodysplastic ...

The association between Xeroderma Pigmentosum DNA repair genes ( XPA rs1800975, XPC rs2228000, XPD rs1799793 and XPF rs1800067) polymorphisms and myelodysplastic syndrome (MDS) have not been reported. To assess the functional role between these polymorphisms and MDS, we evaluated 189 sam- ples stratified in two groups: 95 bone marrow samples from MDS patients and 94 from healthy elderly volunteers used as contr...

Primary cardiac lymphoblastic B‑cell lymphoma : should we treat more intensively?

Primary cardiac lymphoma (PCL) is a rare neoplasm, the majority of cases of which are non‑Hodgkin’s, diffuse large B‑cell (DLBCL). We report the first case of an adult with PCL B‑cell lymphoblastic lymphoma whose disease evolution was grim. A 52‑year‑old male reported dyspnea and facial swelling lasting for 4 months and upon a physical examination he presented bradycardia, jugular venous engorgement, and hypoph...

HFE gene mutation and oxidative damage biomarkers in patients with myelodysplas...

Objective: A relation between transfusional IOL (iron overload), HFE status and oxidative damage was evaluated. Design, setting and participants: An observational cross-sectional study involving 87 healthy individuals and 78 patients with myelodysplastic syndromes (MDS) with and without IOL, seen at University Hospital of the Federal University of Ceará, Brazil, between May 2010 and September 2011. Methods: IOL...

Increased parameters of oxidative stress and its relation to transfusion iron o...

Myelodysplastic syndromes (MDS) are group of stem cell disorders characterised by peripheral cytopaenias and a variable risk of progression to acute myeloid leukaemia. Most patients have anaemia and many develop transfusion dependence and iron overload (IOL), considered to be a negative independent prognostic factor associated with a higher risk of leukemic transformation and shorter survival.