Lyme disease, caused by spirochetes in the Borrelia burgdorferi sensu lato clade within the Borrelia genus, is transmitted by Ixodes ticks and is currently the most prevalent and rapidly expanding tick-borne disease in Europe and North America. We report complete genome sequences of 47 isolates that encompass all established species in this clade while highlighting the diversity of the widespread human pathogen...
We have discovered two unusual restriction endonuclease (ENases) in two Campylobacter jejuni strains that recognize asymmetrical, interrupted sequences and cleave the DNA both before and after their recognition sites. Both enzymes require AdoMet as a cofactor for their ENase activity.