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Splicing factor SF3B1 mutations and ring sideroblasts in myelodysplastic syndro...
Donaires,Flávia Sacilotto; Martelli,Felipe; Alves-Paiva,Raquel de Melo; Magalhães,Silvia Maria Meira; Pinheiro,Ronald Feitosa; Calado,Rodrigo TocantinsABSTRACT Background: Myelodysplastic syndromes (MDS) comprise a group of malignant clonal hematologic disorders characterized by ineffective hematopoiesis and propensity for progression to acute myeloid leukemia. Acquired mutations in the gene encoding RNA splicing factor 3B subunit 1 (SF3B1) are highly associated with the MDS subtypes presenting ring sideroblasts, and represent a specific nosological entity. T...
Comet assay in myelodysplastic syndromes
Teixeira Neto,Paulo Florentino; Pinheiro,Ronald Feitosa; Gonçalves,Romélia Pinheiro
Pioderma gangrenoso bolhoso e síndrome mielodisplásica
Batista,Mariana Dias; Fernandes,Ricardo Limongi; Rocha,Marco Alexandre Dias da; Ikino,Juliana Kida; Pinheiro,Ronald FeitosaO pioderma gangrenoso pode apresentar-se como manifestação paraneoplásica. Relata-se um caso de pioderma gangrenoso, da variante bolhosa, acompanhado de bicitopenia, em que foi evidenciado, por meio de mielograma, biópsia de medula óssea e cariótipo, padrão compatível com síndrome mielodisplásica, subtipo citopenia refratária com displasia de multilinhagens. Foi tratado com dapsona, obtendo cicatrização das les...
Septic arthritis as the first sign of Candida tropicalis fungaemia in an acute ...
Vicari,Perla; Pinheiro,Ronald Feitosa; Chauffaille,Maria de Lourdes Lopes Ferrari; Yamamoto,Mihoko; Figueiredo,Maria StellaFungal infections caused by Candida species have increased in incidence during the past two decades in England, North America and Europe. Candidal arthritis is rare in patients who are not intravenous drug users or are who not using a prostheses. We report the case of a 24-year-old man with acute lymphoid leukemia, who developed Candida tropicalis arthritis during an aplastic period after chemotherapy. This is ...
Low Back Pain During Streptokinase Infusion
Pinheiro,Ronald Feitosa; Pedrolo,Adriana Sanches; Nigri,Marcelo; Carvalho,Antonio Carlos de CamargoWe report the case of a 57-year-old male patient with severe low back pain during streptokinase infusion administered to treat typical chest pain and elevation of the ST segment in the inferior wall. We reviewed the literature, emphasizing the differential diagnosis, the pathophysiology, and management of the event.