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Lessons from Four Decades of Systemic Amyloidosis with Renal Involvement

Oliveira-Silva, C; Marques, N; Pinho, A; Poínhos, Rui; Bergantim, R; Nunes, AT; Sampaio, S; Rodrigues-Pereira, P; Silva, R; Praça, A; Frazão, J

Background: Apart from ATTR amyloidosis, the epidemiology and outcomes of the most common subtypes of systemic amyloidosis in Portugal remain primarily unknown. Methods: This retrospective cohort study evaluated patients with renal biopsy-proven amyloidosis, diagnosed from January 1978 to December 2019. Follow-up started at kidney disease presentation and ended at death or August 2020. Clinical presentation, su...


Comparison of ELISA and HPLC-MS methods for the determination of exenatide in b...

Pinho, A; Fortuna, A; Falcão, A; Santos, AC; Seiça, R; Estevens, C; Veiga, F; Ribeiro, A

The development of biotechnology-based active pharmaceutical ingredients, such as GLP-1 analogs, brought changes in type 2 diabetes treatment options. For better therapeutic efficiency, these active pharmaceutical ingredients require appropriate administration, without the development of adverse effects or toxicity. Therefore, it is required to develop several quantification methods for GLP-1 analogs products, ...


Reactivation of Hepatitis B virus in kidney transplant recipients with previous...

Meng, C; Belino, C; Pereira, L; Pinho, A; Sampaio, S; Tavares, I; Bustorff, M; Sarmento, A; Manuel, P

Background: Hepatitis B virus (HBV) reactivation in kidney transplant recipients (KTR) involves important morbidity and mortality. Despite being more common in patients who are HBsAg-positive, it may occur in patients with clinically resolved infection (HBsAg-negative and anti-HBc-positive), in whom the presence of the protective anti-HB antibody is thought to decrease the risk of reactivation. Data regarding r...


Punched-Out Lesions of the Glans

Pinho, A; Ferreira, B; Moreno, A; Reis, J. P.

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Bezoar gástrico e intestinal: caso clínico e revisão da literatura

Andrade, CS; Lopes, S; Pinheiro, C; Figueiredo, P; Tomé, L; Pinho, A; Martinho, F; Sofia, C; Leitão, M

Os bezoars gastrointestinais são achados relativamente raros, apresentando uma variação regional na sua distribuição relacionada com diferenças na ingestão de alimentos ricos em fibras. A sua verdadeira incidência é desconhecida. A sua ocorrência apresenta uma tendência crescente, em provável relação com a maior taxa de cirurgias gastroduodenais realizadas no último século, consideradas factores de risco para a...


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