114 documents found, page 1 of 12
Modeling microgravity using clinorotation in a microfluidic environment: a nume...
Fernandes, João; Machado, Dara; Minas, Graça; Catarino, Susana Oliveira; Pinho, DianaMicrogravity simulation is essential for studying particle dynamics in space-related applications where traditional gravitational effects are absent. This study presents a numerical investigation of particle behavior in a clinostat-driven microfluidic channel, aiming to simulate microgravity conditions. A computational model was developed in COMSOL Multiphysics to analyze the impact of channel size, particle di...
Evaluating the response of malaria-infected RBCs to magnetic nanocarriers under...
Ferreira, Margarida Gomes; Freitas, Bruno José Ferreira; Baptista, Vitória Cunha; Pinho, Diana; Minas, Graça; Veiga, Maria IsabelMalaria still affects millions of people each year, posing a persistent public health challenge. One major hurdle is the increasing resistance of malaria parasite, Plasmodium falciparum, to the current therapeutic drugs, which calls for alternative treatment strategies. This work takes a first step in exploring whether targeted drug delivery systems using nanocarriers can provide a promising solution to mitigat...
Long-term hydrophilic PDMS surfaces using Brij L4: A simple and robust approach...
Minas, Graça; Pinho, Diana; Borges, Joel; Vaz, Filipe; Zille, Andrea; Lima, Rui Alberto Madeira MacedoPolydimethylsiloxane (PDMS) is a widely used material in the production of microfluidic devices and biomodels, due to its exceptional mechanical, chemical and biocompatible properties. Recently, a novel class of devices known as microphysiological systems have emerged, combining microfluidic technology and cell culture, mimicking the microphysiological features of the human body to facilitate the study of both ...
Necessidades paliativas em estruturas residenciais para pessoas idosas
Pinho, DianaIntrodução: Em Portugal, o envelhecimento demográfico provoca elevados constrangimentos económicos e sociais, devido, essencialmente, ao aumento da esperança média de vida e à diminuição das taxas de natalidade e mortalidade. À medida que se vai conquistando a longevidade, emerge o desafio de prolongar os anos de vida saudáveis e com qualidade. A estratégia para garantir a proteção social em Portu...
Advances in Microfluidic Systems and Numerical Modeling in Biomedical Applicati...
Ferreira, Mariana; Carvalho, Violeta Meneses; Ribeiro, J.E.; Lima, Rui A.; Teixeira, Senhorinha F.C.F.; Pinho, DianaThe evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing importance for better understanding and predicting fluid-flow behavior in microscale devices. This review explores fabrication techniques and common materials of m...
Experimental Investigation of Green Nanofluids: Assessment of Wettability, Visc...
Nobrega, Glauco; Cardoso, Beatriz D.; Barbosa, Filipe; Pinho, Diana; Abreu, Cristiano; Souza, Reinaldo Rodrigues de; Moita, Ana S.; Ribeiro, J.E.Metallic nanoparticles are a type of nanomaterial synthesized from metallic precursors. Due to their unique physiochemical, electrical, and optical properties, metallic nanoparticles are widely studied and applied in various areas such as medicine, electronics, and heat transfer systems. However, conventional synthesis methods to produce metallic nanoparticles face challenges such as instability and environment...
Development and fabrication of a microfluidic device for mechanical characteriz...
Ferreira, Margarida Gomes; Freitas, Bruno; Baptista, Vitória; Pinho, Diana; Minas, Graça; Veiga, Maria Isabel; Faustino, Vera; Catarino, Susana OliveiraThis work reports the design and fabrication of a polymeric microfluidic device, with a hyperbolic contraction, to promote extensional flow and allow the single cell mechanical characterization, in vitro, of healthy and malaria-infected red blood cells (RBCs). The obtained results show an extensional flow profile of the velocity across the microchannel for both healthy and infected RBCs, while the ability of th...
Polydimethylsiloxane surface modification of microfluidic devices for blood pla...
Gonçalves, Margarida; Gonçalves, Inês Maia; Borges, Joel; Faustino, Vera Luísa Carreira; Soares, Delfim; Vaz, Filipe; Minas, GraçaOver the last decade, researchers have developed a variety of new analytical and clinical diagnostic devices. These devices are predominantly based on microfluidic technologies, where biological samples can be processed and manipulated for the collection and detection of important biomolecules. Polydimethylsiloxane (PDMS) is the most commonly used material in the fabrication of these microfluidic devices. Howev...
Advances in microfluidic systems and numerical modeling in biomedical applicati...
Ferreira, Mariana; Carvalho, Violeta Meneses; Ribeiro, João; Lima, Rui Alberto Madeira Macedo; Teixeira, S. F. C. F.; Pinho, DianaThe evolution in the biomedical engineering field boosts innovative technologies, with microfluidic systems standing out as transformative tools in disease diagnosis, treatment, and monitoring. Numerical simulation has emerged as a tool of increasing importance for better understanding and predicting fluid-flow behavior in microscale devices. This review explores fabrication techniques and common materials of m...
A review of novel heat transfer materials and fluids for aerospace applications
Nobrega, Glauco; Cardoso, Beatriz; Souza, Reinaldo; Pereira, José; Pontes, Pedro; Catarino, Susana Oliveira; Pinho, DianaThe issue of thermal control for space missions has been critical since the early space missions in the late 1950s. The demands in such environments are heightened, characterized by significant temperature variations and the need to manage substantial densities of heat. The current work offers a comprehensive survey of the innovative materials and thermal fluids employed in the aerospace technological area. In ...