3 documents found, page 1 of 1
Liposomal delivery of repurposed antiviral drug saquinavir to macrophages as a ...
Mandal, Manoj; Pires, David; Pinho, Jacinta; Catalão, Maria João; Almeida, António José; Azevedo-Pereira, José Miguel; Gaspar, Maria Manuela; Anes, ElsaMycobacterium tuberculosis (Mtb) latently infects approximately a quarter of the world’s population and 10 % of these will develop the disease tuberculosis. Mtb infects macrophages, manipulating the proteolytic mechanisms, particularly, by decreasing the expression and activity of lysosomal cathepsins. Consequently, Mtb survives and even replicates inside macrophages concomitant with poor priming of the adaptiv...
Liposomal delivery of saquinavir to macrophages overcomes cathepsin blockade by...
Pires, David; Mandal, Manoj; Pinho, Jacinta; Catalão, Maria João; Almeida, António José; Azevedo-Pereira, José Miguel; Gaspar, Maria Manuela; Anes, ElsaMycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a controlled replication manner, giving rise to a so-called latent infection. Conversely, when intracellular bacteria undergo actively uncontrolled replication rates, they provide the switch for the active infection called tuberculosis to occur. Our group found that the pathogen is able to manipulate the activity of en...
Inhalable locust bean gum microparticles co-associating isoniazid and rifabutin...
Grenha, Ana; Alves, Ana D.; Guerreiro, Filipa; Pinho, Jacinta; Simões, Sandra; Almeida, António José; Gaspar, Maria ManuelaTuberculosis is a leading cause of death worldwide. Although the development of new antimycobacterial drugs is an obvious and necessary strategy to address the disease, improving the therapeutic performance of drugs already approved constitutes a valuable alternative approach. As the lung is the most affected organ, where M. tuberculosis is able to survive and proliferate, the direct pulmonary delivery of antit...