4 documents found, page 1 of 1
Preclinical validation of a new hybrid molecule loaded in liposomes for melanom...
Pinho, Jacinta O.; Matias, Mariana; Marques, Vanda; Eleutério, Carla; Fernandes, Célia; Gano, Lurdes; Amaral, Joana D.; Mendes, EduardaThe aggressiveness of melanoma and lack of effective therapies incite the discovery of novel strategies. Recently, a new dual acting hybrid molecule (HM), combining a triazene and a ʟ-tyrosine analogue, was synthesized. HM was designed to specifically be activated by tyrosinase, the enzyme involved in melanin biosynthesis and overexpressed in melanoma. HM displayed remarkable superior antiproliferative activity...
Liposomal Delivery of Saquinavir to Macrophages Overcomes Cathepsin Blockade by...
Pires, David; Mandal, Manoj; Pinho, Jacinta O.; Catalão, Maria João; Almeida, António J.; Azevedo-Pereira, J. M.; Gaspar, Maria Manuela; Anes, ElsaMycobacterium tuberculosis is able to establish a chronic colonization of lung macrophages in a controlled replication manner, giving rise to a so-called latent infection. Conversely, when intracellular bacteria undergo actively uncontrolled replication rates, they provide the switch for the active infection called tuberculosis to occur. Our group found that the pathogen is able to manipulate the activity of en...
Cancer chemotherapeutic agents using a nanotechnological approach
Pinho, Jacinta O.The complexity and aggressiveness of cancer, as well as its increasing incidence and mortality worldwide, prompts the search for novel and alternative therapeutic strategies with improved effectiveness and safety. In this sense, the identification of therapeutic targets, the discovery of new molecules with antitumor potential, and the design of drug delivery systems create opportunities for a successful cancer ...
The aquaporin-3-inhibiting potential of polyoxotungstates
Pimpão, Catarina; da Silva, Inês V.; Mósca, Andreia F.; Pinho, Jacinta O.; Gaspar, Maria Manuela; Gumerova, Nadiia I.; Rompel, AnnettePolyoxometalates (POMs) are of increasing interest due to their proven anticancer activities. Aquaporins (AQPs) were found to be overexpressed in tumors bringing particular attention to their inhibitors as anticancer drugs. Herein, we report for the first time the ability of polyoxotungstates (POTs), such as of Wells-Dawson P2W18, P2W12, and P2W15, and Preyssler P5W30 structures, to affect aquaporin-3 (AQP3) ac...