3 documents found, page 1 of 1
Author Correction: Efficient spatially targeted gene editing using a near-infra...
Rebelo, Catarina; Reis, Tiago; Guedes, Joana; Saraiva, Cláudia; Rodrigues, Artur Filipe; Simões, Susana; Bernardino, Liliana; Peça, João
Efficient spatially targeted gene editing using a near-infrared activatable pro...
Rebelo, Catarina; Reis, Tiago; Guedes, Joana; Saraiva, Cláudia; Rodrigues, Artur Filipe; Simões, Susana; Bernardino, Liliana; Peça, JoãoSpatial control of gene expression is critical to modulate cellular functions and deconstruct the function of individual genes in biological processes. Light-responsive gene-editing formulations have been recently developed; however, they have shown limited applicability in vivo due to poor tissue penetration, limited cellular transfection and the difficulty in evaluating the activity of the edited cells. Here,...
Therapeutic Approaches for Stroke: A Biomaterials Perspective
Rodrigues, Artur Filipe; Rebelo, Catarina; Reis, Tiago; Sousa, João André; Pinho, Sónia L. C.; Sargento-Freitas, João; Peça, João; Ferreira, LinoStroke is a leading cause of death worldwide and poses significant societal and healthcare challenges due to functional impairment of the brain. In order to fully restore brain function, innovative approaches have aimed to regenerate the injured tissue and to restore neuronal circuitry. In the last 5 years, stem cells have been consistently explored in clinical trials for tissue regeneration. Recent technologic...