15 documents found, page 1 of 2

Glycans as Key Checkpoints of T Cell Activity and Function

The immune system is highly controlled and fine-tuned by glycosylation, through the addition of a diversity of carbohydrates structures (glycans) to virtually all immune cell receptors. Despite a relative backlog in understanding the importance of glycans in the immune system, due to its inherent complexity, remarkable findings have been highlighting the essential contributions of glycosylation in the regulatio...

[CR-POSSUM and Surgical Apgar Score as predictive factors for patients' allocat...

Background and objectives: Surgical patients frequently require admission in high-dependency units or intensive care units. Resources are scarce and there are no universally accepted admission criteria, so patients' allocation must be optimized. The purpose of this study was to investigate the relationship between postoperative destination of patients submitted to colorectal surgery and the scores ColoRectal Ph...

Metabolic control of T cell immune response through glycans in inflammatory bow...

Mucosal T lymphocytes from patients with ulcerative colitis (UC) were previously shown to display a deficiency in branched N-glycosylation associated with disease severity. However, whether this glycosylation pathway shapes the course of the T cell response constituting a targeted-specific mechanism in UC remains largely unknown. In this study, we demonstrated that metabolic supplementation of ex vivo mucosal T...

Anaesthesia - related fears - a cross - sectional survey among the portuguese p...

Introduction: Patients experience preoperative anxiety. The objective of this study was to assess patients’ fears concerning anaesthesia and evaluate possible associations with sociodemographic background and previous anaesthesia. Methods: A survey was filled preoperatively, for 6 months, including anaesthesia-related fears, sociodemographic data, previous anaesthesia and surgery, current surgical and anaesthet...

Caracterização sociográfica dos Ortoprotésicos licenciados na Escola Superior d...

O objetivo do artigo proposto é apresentar os traços gerais da caracterização sociográfica dos ortoprotésicos licenciados pela Escola Superior de Tecnologia da Saúde de Lisboa (ESTeSL), considerando quatro dimensões: 1) perfil social e profissional, 2) condições de trabalho, 3) grau de autonomia, 4) principais problemas e projetos profissionais. A caracterização sociográfica exposta neste artigo resultou de um ...

Versão portuguesa do inventário das cognições associadas à mania

Bipolar remitted patients show emotion-related bias in memories of lifelike eve...

This study aimed to examine whether patients with bipolar disorder (BD) perceive differences in the encoding and retrieving of autobiographical information related to events with different emotional valence. For this purpose, an experimental task based on the virtual reality paradigm was administrated to 14 euthymic BD patients and 23 healthy controls. All participants also had a neuropsychological assessment a...

Antibiotic consumption in Portugal: 2010 and 2011

The use of antibiotics has contributed to a marked decrease in morbidity caused by communicable and infec- tious diseases over the past few years. The aim of our study is to evaluate the use of antibiotics in clinic in 2010 and 2011, considering two different methodologies: the defined daily dose per 1000 inhabitants per day (DHD) and the number of packages per 1000 inhabitants per day (PHD).

Urinary tract infections: outpatient antibiotic use and antimicrobial resistanc...

Background and objective: Microbial resistance to antibiotics continues to emerge as a significant global health concern. The misuse of antibiotics is an important factor contributing to the development of antibiotic resistance by bacteria. Urinary tract infection is among the most common bacterial infections, being Escherichia coli the main etiological agent.

Expressão de grelina no olho e a sua implicação na redução da pressão int...

Objectivo: Avaliar a distribuição da grelina e do seu receptor (GHSR-1) no globo ocular de rato adulto e avaliar o papel da grelina na modulação da pressão intra-ocular (PIO) em modelos animais de glaucoma agudo. Métodos: Foi realizada imunolocalização da grelina e seu receptor (GHSR-1) em ratos machos adultos Wistar (300-480g). Foi induzido glaucoma agudo em coelhos brancos Neozelandeses (2.0 – 3.0 Kg)...