21 documents found, page 1 of 3
The role of N-glycans in regulatory T cells in autoimmunity
Carneiro, P; Vicente, MM; Leite, MI; Santos, ME; Pinho, SS; Fernandes, ÂRegulatory T cells (Tregs) have a key role in the maintenance of immune tolerance and in the prevention of autoimmunity. Recent studies have shown an association between decreased Treg frequency and a deficient suppressive activity with the development of many autoimmune diseases. Although glycosylation, which consists in the addition of glycans to proteins and lipids on the cell surface, is recognized as a cri...
TASTY trial: protocol for a study on the triad of nutrition, intestinal microbi...
Charneca, S; Hernando, A; Almada-Correia, I; Polido-Pereira, J; Vieira, A; Sousa, J; Almeida, AS; Motta, C; Barreto, G; Eklund, KK; Alonso-Pérez, ABackground The gut microbiota has been implicated in the onset and progression of Rheumatoid Arthritis (RA). It has been proposed that gut dysbiosis impairs gut barrier function, leading to alterations in mucosal integrity and immunity. This disruption allows bacterial translocation, contributing to the perpetuation of the inflammatory process. Since diet is recognised as a key environmental factor influencing ...
"Mannose glycans as key players in trained immunity: A novel anti-tumoral catal...
Almeida, P; Alves, I; Fernandes, Â; Lima, C; Freitas, R; Braga, I; Correia, J; Jerónimo, C; Pinho, SSCell wall glycans isolated from microorganisms are long known to provoke strong immune responses piloted by innate immune cell populations, including monocytes, in the context of Trained Immunity (TI). However, the contribution of yeast-derived mannan in the reprogramming of monocytes remains ill-defined. Here, we demonstrated that TI is often accompanied by an altered gene expression profile of selected glycan...
Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation o...
Rodrigues, CS; Gaifem, J; Pereira, MS; Alves, MF; Silva, M; Padrão, N; Cavadas, B; Moreira-Barbosa, C; Alves, I; Marcos-Pinto, R; Torres, J; Lavelle, AThe perturbation of the symbiotic relationship between microbes and intestinal immune system contributes to gut inflammation and Inflammatory Bowel Disease (IBD) development. The host mucosa glycans (glycocalyx) creates a major biological interface between gut microorganisms and host immunity that remains ill-defined. Glycans are essential players in IBD immunopathogenesis, even years before disease onset. Howe...
Reprogramming CD8+ T-cell Branched N-Glycosylation Limits Exhaustion, Enhancing...
Azevedo, CM; Xie, B; Gunn, WG; Peralta, RM; Dantas, CS; Fernandes-Mendes, H; Joshi, S; Dean, V; Almeida, P; Wilfahrt, D; Mendes, N; Portero, JLT-cell therapies have transformed cancer treatment. While surface glycans have been shown to play critical roles in regulating T-cell development and function, whether and how the glycome influences T cell–mediated tumor immunity remains an area of active investigation. In this study, we show that the intratumoral T-cell glycome is altered early in human colorectal cancer, with substantial changes in branched N...
T-cell branched glycosylation as a mediator of colitis-associated colorectal ca...
Leite-Gomes, E; Silva, MC; Dias, AM; Fernandes, Â; Faria, G; Nogueira, R; Santos-Pereira, B; Fernandes-Mendes, H; Azevedo, CM; Raposo, J; Portero, JLBackground and Aims: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract, established as a risk factor for colorectal cancer (CRC) development. Long-standing inflammation appears to play a central role in colitis-associated colorectal cancer (CAC). However, the molecular mechanism underlying CAC progression is still elusive. Previous evidence showed that levels of b...
Glycans in Trained Immunity: Educators of innate immune memory in homeostasis a...
Almeida, P; Fernandes, Â; Alves, I; Pinho, SSTrained Immunity is defined as a biological process normally induced by exogenous or endogenous insults that triggers epigenetic and metabolic reprogramming events associated with long-term adaptation of innate immune cells. This trained phenotype confers enhanced responsiveness to subsequent triggers, resulting in an innate immune "memory" effect. Trained Immunity, in the past decade, has revealed important be...
The role of glycans in health and disease: Regulators of the interaction betwee...
Crouch, LI; Rodrigues, CS; Bakshani, CR; Tavares-Gomes, L; Gaifem, J; Pinho, SSThe human gut microbiota is home to a diverse collection of microorganisms that has co-evolved with the host immune system in which host-microbiota interactions are essential to preserve health and homeostasis. Evidence suggests that the perturbation of this symbiotic host-microbiome relationship contributes to the onset of major diseases such as chronic inflammatory diseases including Inflammatory Bowel Diseas...
A unique serum IgG glycosylation signature predicts development of Crohn’s dise...
Gaifem, J; Rodrigues, CS; Petralia, F; Alves, I; Leite-Gomes, E; Cavadas, B; Dias, AM; Moreira-Barbosa, C; Revés, J; Laird, RM; Novokmet, M; Štambuk, JInflammatory bowel disease (IBD) is characterized by chronic inflammation in the gut. There is growing evidence in Crohn’s disease (CD) of the existence of a preclinical period characterized by immunological changes preceding symptom onset that starts years before diagnosis. Gaining insight into this preclinical phase will allow disease prediction and prevention. Analysis of preclinical serum samples, up to 6 y...
Glycome dynamics in T and B cell development: basic immunological mechanisms an...
Vicente, MM; Leite-Gomes, E; Pinho, SSGlycans cover the surfaces of all mammalian cells through a process called glycosylation. Nearly all proteins and receptors that integrate the intricate series of co-stimulatory/inhibitory pathways of the immune system are glycosylated. Growing evidence indicates that the development of the immune system at the origins of T and B cell development is tightly regulated by glycosylation. In this opinion, we hypoth...