Oncostatin M (OSM) and leukemia inhibitory factor (LIF) are pleiotropic cytokines from the interkeukine-6 family, associated with several disorders, and present significant potential in biomedicine. However, their therapeutic use is highly constrained by factors such as short circulating half-life and narrow therapeutic window. The conjugation of cytokines with elastin-like recombinamers (ELR) holds the potenti...
Objective: This study sought to understand the participation of the Mental Health Council in the policy of the Psychosocial Care Network according to the view of health professionals. Method: This is an Integrative Review that allows the search and critical analysis of scientific production related to the research theme, where the six steps of Mendes, Silveira and Galvão and the PCC strategy (P=Population, C=Co...
"In Press, Journal Pre-proof"; Leukemia inhibitory factor (LIF) is a pleiotropic cytokine with several functions in health and disease ranging from inflammation to cancer. LIF is also a potential target and/or therapeutic agent for diseases such as multiple sclerosis, stroke and even psychological disorders, where the function of LIF as a neurotrophic factor has only recently been explored. In recent years, a l...
UID/BIA/04050/2019, funded by national funds through the FCT IP, and project FUN2CYT: Harnessing the potential for biomedical applications of pleiotropic cytokines LIF and oncostatin M (PTDC/BTM-MAT/30568/2017, POCI-01-0145-FEDER-030568) supported by POCI through FEDER and FCT IP; info:eu-repo/semantics/publishedVersion
Este relatório enquadra-se no âmbito do Estágio de Mestrado em Educação Pré-escolar e 1º Ciclo do Ensino Básico. Este tem como principal objetivo dar a conhecer a prática vivenciada no âmbito de estágio na Educação Pré-escolar e no 1º Ciclo do Ensino Básico. Com a sua elaboração é possível compreender de um modo mais aprofundado como se desenvolvem as duas valências, realçando as suas principais semelhanças e d...