37 documents found, page 1 of 4
Novel tetradentate N2O2 water-soluble Schiff Base and its Al(III) complex: synt...
Bouznif, Hajer; Justino, Licínia L. G.; Soares, Maria I. L.; Costa, Telma; Ramos, Maria Luisa; Nikitin, Timur; Pinho e Melo, Teresa M. V. D.A novel water-soluble di-Schiff base, N,N’-bis(3-methoxy-5-sulfonatosalicylidene)-1,2- ethylenediamine disodium salt (MSS), was synthesized under both conventional heating and microwave-assisted conditions. Detailed characterization was conducted using various techniques including NMR, HRMS, UV_vis, SEM/EDX, DSC, ATR-FTIR and Raman spectroscopies, accompanied by DFT calculations. The study discusses the enol-im...
Effectiveness of photodynamic therapy on treatment response and survival of pat...
Cardoso, Miguel; Marto, Carlos Miguel; Paula, Anabela; Coelho, Ana Sofia; Pinho e Melo, Teresa M. V. D.; Ferreira, Manuel M.; Botelho, Maria FilomenaObjective: This review aims to systematically examine the effectiveness of photodynamic therapy for the treatment of patients with recurrent oral squamous cell carcinoma. Introduction: Oral squamous cell carcinoma is a significant public health problem, and is the seventh most common cancer. Its incidence is mainly due to tobacco use, alcohol consumption, and HPV infection. The survival rates are poor due to di...
Flow Chemistry: Sequential Flow Processes for the Synthesis of Heterocycles
Brandão, Pedro; Piñeiro, Marta; Pinho e Melo, Teresa M. V. D.Flow chemistry is changing the face of synthetic organic chemistry laboratories in both academia and industry. The application of continuous flow processes for multistep reactions is becoming a golden rule for the sustainable synthesis of heterocycles. In this chapter, several recent examples of the application of flow processes for the synthesis of relevant heterocycles, including active pharmaceutical ingredi...
Insights into the anticancer activity of chiral alkylidene-β-lactams and alkyli...
Alves, Américo J. S.; Alves, Nuno G.; Laranjo, Mafalda; Gomes, Clara S. B.; Gonçalves, Ana Cristina; Ribeiro, Ana Bela Sarmento; Botelho, M. FilomenaChiral alkylidene-β-lactams and alkylidene-γ-lactams were synthesized and screened for their in vitro activity against four human cancer cell lines (melanoma, esophageal, lung and fibrosarcoma carcinoma). Alkylidene-β-lactams were synthesized via Wittig reaction of diverse phosphorus ylides with benzhydryl 6-oxopenicillanate, derived from 6-aminopenicillanic acid. Moreover, novel chiral alkylidene-γ-lactams wer...
Applications of Photodynamic Therapy in Endometrial Diseases
Correia-Barros, Gabriela; Serambeque, Beatriz; Carvalho, Maria João; Marto, Carlos Miguel; Pineiro, Marta; Pinho e Melo, Teresa M. V. D.Photodynamic therapy (PDT) is a medical procedure useful for several benign conditions (such as wound healing and infections) and cancer. PDT is minimally invasive, presents few side effects, good scaring, and is able to minimal tissue destruction maintaining organ anatomy and function. Endoscopic access to the uterus puts PDT in the spotlight for endometrial disease treatment. This work systematically reviews ...
Ring-Fused meso-Tetraarylchlorins as Auspicious PDT Sensitizers: Synthesis, Str...
Laranjo, Mafalda; Pereira, Nelson A. M.; Oliveira, Andreia S. R.; Aguiar, Márcia Campos; Brites, Gonçalo Sousa; Nascimento, Bruno F. O.Novel 4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-fused meso-tetraarylchlorins, with different degrees of hydrophilicity (with methyl ester, hydroxymethyl, and carboxylic acid moieties), have been synthesized and their photophysical characterization as well as in vitro photocytotoxicity assessment against human melanoma and esophageal and bladder carcinomas was carried out. An integrated analysis of the photosens...
Cholesteryl hemiazelate causes lysosome dysfunction impacting vascular smooth m...
Alves, Liliana S.; Marques, André R. A.; Padrão, Nuno; Carvalho, Filomena A.; Ramalho, José; Lopes, Catarina S.; Soares, Maria I. L.; Futter, Clare E.In atherosclerotic lesions, vascular smooth muscle cells (VSMCs) represent half of the foam cell population, which is characterized by an aberrant accumulation of undigested lipids within lysosomes. Loss of lysosome function impacts VSMC homeostasis and disease progression. Understanding the molecular mechanisms underlying lysosome dysfunction in these cells is, therefore, crucial. We identify cholesteryl hemia...
Global Women’s Breakfast (GWB): #UnidaspelaQuímica
Aguiar-Ricardo, Ana; Alves, Arminda; Antunes, M. Cristina; Batalha, Filipa; Oliveira Brett, Ana Maria; Camões, Filomena; Cardoso, Ana L.Global Women’s Breakfast (GWB): #BoundbyChemistry. Global Women’s Breakfast is an initiative of the International Union of Pure and Applied Chemistry, aiming to give women scientists, from all over the world, the opportunity to know each other, communicating virtually and sharing their experiences. Many countries joined this initiative and Portugal was not an exception, with its participation already at the fir...
Ethyl 7-Acetyl-8a-methyl-3-(1-phenyl-1H-tetrazol-5-yl)-1,4,4a,5,6,8a-hexahydro-...
Lopes, Susana M. M.; Lemos, Americo; Paixão, José A.; Pinho e Melo, Teresa M. V. D.The Diels–Alder reaction of ethyl 3-(1-phenyl-1<i>H</i>-tetrazol-5-yl-1,2-diaza-1,3-butadiene-1-carboxylate with 2-acetyl-6-methyl-2,3-dihydro-4<i>H</i>-pyran (methyl vinyl ketone dimer) regioselectively afforded the corresponding 3-(tetrazol-5-yl)-hexahydro-7<i>H</i>-pyrano[2,3-<i>c</i>]pyridazine in quantitative yield. An X-ray crystal structure of this cycloadduct is reported.
Switching on H-Tunneling through Conformational Control
Roque, José P. L.; Nunes, Cláudio M.; Viegas, Luís P.; Pereira, Nelson A. M.; Pinho e Melo, Teresa M. V. D.; Schreiner, Peter R.; Fausto, RuiH-tunneling is a ubiquitous phenomenon, relevant to fields from biochemistry to materials science, but harnessing it for mastering the manipulation of chemical structures still remains nearly illusory. Here, we demonstrate how to switch on H-tunneling by conformational control using external radiation. This is outlined with a triplet 2-hydroxyphenylnitrene generated in an N2 matrix at 10 K by UV-irradiation of ...