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Usefulness of zebrafish larvae to evaluate drug-induced functional and morpholo...

Gorgulho, R.; Jacinto, R.; Lopes, S.S.; SA, Pereira; Tranfield, E.M.; Martins, G.G.; Gualda, E.J.; Derks, R.J.E.; Correia, A.C.; Steenvoorden, E.

Prediction and management of drug-induced renal injury (DIRI) rely on the knowledge of the mechanisms of drug insult and on the availability of appropriate animal models to explore it. Zebrafish (Danio rerio) offers unique advantages for assessing DIRI because the larval pronephric kidney has a high homology with its human counterpart and it is fully mature at 3.5 days post-fertilization. Herein, we aimed to ev...


Dynamics of cilia length in left–right development

Pintado, P.; Sampaio, P.; Tavares, B.; Montenegro-Johnson, T.D.; Smith, D.J.; Lopes, S.S.

This work was supported by the Fundacao para a Ciencia e a Tecnologia (FCT-ANR/BEX-BID/0153/2012 research grant). T.D.M.-J. was supported by a Royal Commission for the Exhibition of 1851 Fellowship. S.S.L. was funded by FCT Investigator IF/00951/2012. B.T. was funded by FCT fellowship SFRH/BPD/77258/2011 and P.P. and P.S. were funded by the FCT-ANR/BEX-BID/0153/2012 research grant.; Reduction in the length of m...


The role of Rabconnectin3a in cilia length regulation

Tavares, B.; Pintado, P.; Lopes, S.S.


Arl13b interferes with α-tubulin acetylation

Pintado, P.; Seixas, C.; Barral, Duarte C.; Lopes, S.S.


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