5 documents found, page 1 of 1
Minimalist tissue engineering approaches using low material-based bioengineered...
Correia, Clara; Bjorge, Isabel M.; Nadine, Sara; Mano, João F.From an “over-engineering” era in which biomaterials played a central role, now it is observed to the emergence of “developmental” tissue engineering (TE) strategies which rely on an integrative cell-material perspective that paves the way for cell self-organization. The current challenge is to engineer the microenvironment without hampering the spontaneous collective arrangement ability of cells, while simulta...
Nanogrooved microdiscs for bottom-up modulation of osteogenic differentiation
Bjorge, Isabel M.; Choi, Insung S.; Correia, Clara R.; Mano, João F.Grooved topographical features have effectively modulated cell differentiation on two-dimensional substrates. To transpose patterning into a 3D environmment, nanogrooved microdiscs, "topodiscs", are produced as cell carriers for bottom-up cell-mediated assembly. While enhancing cell proliferation, topodiscs led to the formation of bone-like aggregates, even in culture medium lacking osteoinductive factors.
Liquefied microcapsules as dual-Mmcrocarriers for 3D+3D bottom-up tissue engine...
Correia, Clara R.; Bjorge, Isabel M.; Zeng, Jinfeng; Matsusaki, Michiya; Mano, João F.Cell encapsulation systems must ensure the diffusion of molecules to avoid the formation of necrotic cores. The architectural design of hydrogels, the gold standard tissue engineering strategy, is thus limited to a microsize range. To overcome such a limitation, liquefied microcapsules encapsulating cells and microparticles are proposed. Microcapsules with controlled sizes with average diameters of 608.5 ± 122....
Tuneable spheroidal hydrogel particles for cell and drug encapsulation
Bjorge, Isabel M.; Costa, Ana M. S.; Sofia Silva, A.; Vidal, Joao P. O.; Nóbrega, J. M.; Mano, J. F.The need to better mimic native tissues has accompanied research in tissue engineering and controlled drug delivery. The development of new platforms for cell and drug encapsulation followed the same trend, and studying the influence of the delivery material system's geometry has been gaining momentum. Aiming to investigate how an increase in surface area and varying particle shape could impact drug release and...
Tuneable spheroidal hydrogel particles for cell and drug encapsulation
Bjorge, Isabel M.; Costa, Ana M. S.; Silva, A. Sofia; Vidal, João P. O.; Nóbrega, J. Miguel; Mano, João F.The need to better mimic native tissues has accompanied research in tissue engineering and controlled drug delivery. The development of new platforms for cell and drug encapsulation followed the same trend, and studying the influence of the delivery material system's geometry has been gaining momentum. Aiming to investigate how an increase in surface area and varying particle shape could impact drug release and...