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Glucosylated cholesterol accumulates in atherosclerotic lesions and impacts mac...
Marques, André R.A.; Ferreira, Inês; Ribeiro, Quélia; Ferraz, Maria J.; Lopes, Elizeth; Pinto, Daniela; J. Hall, Michael; JS, Ramalho; Artola, MartaAtherosclerosis can be described as a local acquired lysosomal storage disorder (LSD), resulting from the build-up of undegraded material in lysosomes. Atherosclerotic foam cells accumulate cholesterol (Chol) and glycosphingolipids (GSLs) within lysosomes. This constitutes the ideal milieu for the formation of a side product of lysosomal storage: glucosylated cholesterol (GlcChol), previously found in several L...
Data: 2025
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Origem: Repositório Institucional da UNL