9 documents found, page 1 of 1
Effects of Periploca chevalieri Browicz on Postprandial Glycemia and Carbohydra...
Lima, Katelene; Malmir, Maryam; Sabiha, Shabnam; Pinto, Rui; Silva, Isabel Moreira da; Figueira, Maria Eduardo; Rocha, João; Duarte, Maria PaulaFunding Information: This research was funded by the Foundation for Science and Technology (FCT, Portugal) through national funds to iMed.ULisboa (UIDP/04138/2020) and to the Mechanical Engineering and Resource Sustainability Center—MEtRICs unit, which is funded by national funds from FCT/MCTES (UIDB/04077/2020 and UIDP/04077/2020). Publisher Copyright: © 2025 by the authors.; Background/Objectives: Periploca c...
Diagnóstico da Doença Renal Crónica em Adultos em Portugal
Malheiro, Jorge; Birne, Rita; Biscaia, André; Almeida, Edgar; Nobre, João; Capela, Nuno; Azinheira, Jorge; Nunes Oliveira, Jorge; Lebre, LuísPublisher Copyright: Copyright © Ordem dos Médicos 2025.; Chronic kidney disease represents a significant public health issue, affecting approximately 9.8% of the adult population in Portugal. Despite this figure, early diagnosis of this disease in high-risk groups remains limited. Although only two parameters are essential for its diagnosis – estimated glomerular filtration rate (eGFR) and albuminuria – in Por...
A small TAT-TrkB peptide prevents BDNF receptor cleavage and restores synaptic ...
Fonseca-Gomes, João; Costa-Coelho, Tiago; Ferreira-Manso, Mafalda; Inteiro-Oliveira, Sara; Vaz, Sandra H.; Alemãn-Serrano, NunoPublisher Copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.; In Alzheimer's disease (AD), amyloid β (Aβ)-triggered cleavage of TrkB-FL impairs brain-derived neurotrophic factor (BDNF) signaling, thereby compromising neuronal survival, differentiation, and synaptic transmission and plasticity. Using cerebrospinal fluid and postmortem human brain samples, we show that TrkB...
Contribution to the Preclinical Safety Assessment of Lannea velutina and Sorind...
Malú, Quintino; Lima, Katelene; Malmir, Maryam; Pinto, Rui; da Silva, Isabel Moreira; Catarino, Luís; Duarte, Maria Paula; Serrano, Rita; Rocha, JoãoFunding Information: This research was funded by the Foundation for Science and Technology (FCT, Portugal) through national funds FCT/MCTES to MEtRICs (UIDPB/04077/2020). Publisher Copyright: © 2022 by the authors.; Dried leaves of Lannea velutina A. Rich. and Sorindeia juglandifolia (A. Rich.) Planch. ex Oliv. (family Anacardiaceae) are used in African traditional medicine. Although these medicinal plants have...
Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal can...
Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; Casimiro, SandraWe thank João Neto and remaining Computational Multi-Omics Lab members at UCIBIO for their helpful comments and suggestions. © 2022. The Author(s).; Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in ...
How can biomolecules improve mucoadhesion of oral insulin? A comprehensive insi...
Amaral, Mariana; Martins, Ana Sofia; Catarino, José; Faísca, Pedro; Kumar, Pradeep; Pinto, João F.; Pinto, Rui; Correia, Isabel; Ascensão, LiaFunding: Supported in part by UID/DTP/04138/2019 from FCT, Portugal and DREAMS (ULHT). SEM analysis was funded by FCT/MCTES for the financial support to CESAM (UIDP/50017/2020+UIDB/50017/2020), through national funds.; Currently, insulin can only be administered through the subcutaneous route. Due to the flaws associated with this route, it is of interest to orally deliver this drug. However, insulin delivered ...
Phytosomes with persimmon (Diospyros kaki l.) extract
Direito, Rosa; Reis, Catarina; Roque, Luís; Gonçalves, Margarida; Sanches-Silva, Ana; Gaspar, Maria Manuela; Pinto, Rui; Rocha, João; Sepodes, BrunoThis research was funded by Universidade de Lisboa PhD grant: REITORIA/BD/FF01/2015. supported in part through Grant UID/DTP/04138/2019 from Fundação para a Ciência e a Tecnologia (FCT), Portugal.; Persimmon (Diospyros kaki L.), a fruit rich in phenolic compounds (PCs), has been considered effective in mitigating oxidative damage induced by an excess of reactive oxygen species. Due to large molecular weight and...
Reduction of Inflammation and Colon Injury by a Spearmint Phenolic Extract in E...
Direito, Rosa; Rocha, João; Lima, Ana; Gonçalves, Maria Margarida Boavida Pontes; Duarte, Maria Paula Amaro de Castilho; Mateus, VanessaBackground: Inflammatory Bowel Diseases (IBD) encompasses both Crohn’s Disease and Ulcerative Colitis, known to be connected to an enlarged risk for developing colorectal cancer (CRC). Spearmint (Mentha spicata L.) is a Mediterranean plant used as an aromatic agent, and studies have mainly focused on the essential oil suggesting an anti-inflammatory activity. This work aimed to perform a preliminary screening o...
Genotoxic effects of occupational exposure to lead and influence of polymorphis...
García-Lestón, J; Roma-Torres, J; Vilares, M; Pinto, Rui; Prista, João; Teixeira, João P.; Mayan, Olga; Conde, João; Pingarilho, MartaThis work was partly supported by the Spanish Ministry of Science and Innovation (PSI2010-15115) and Portuguese Fundação para a Ciência e a Tecnologia (grants PDCT/SAU-OBS/59821/2004, PTDC/QUI/ 67522/2006 and PTDC/SAU-OSM/105572/2008, and fellowship SFRH/ BD/22612/2005 to M. Pingarilho).