6 documents found, page 1 of 1
Intracellular autofluorescence as a new biomarker for cancer stem cells in glio...
Castro, Joana Isabel Martins Cosme Vieira; Gonçalves, Celine Saraiva; Martins, Eduarda P.; Miranda-Lorenzo, Irene; Cerqueira, Mariana TeixeiraThe identification of cancer stem cells (CSCs), which are implicated in tumor initiation, progression, therapy resistance, and relapse, is of great biological and clinical relevance. In glioblastoma (GBM), this is still a challenge, as no single marker is able to universally identify populations of GBM cancer stem cells (GSCs). Indeed, there is still controversy on whether biomarker-expressing cells fulfill the...
A novel molecular link between HOXA9 and WNT6 in glioblastoma identifies a subg...
Gonçalves, Céline S.; Xavier‐Magalhães, Ana; Martins, Eduarda P.; Pinto, Afonso A.; Pires, Manuel; Pinheiro, Célia; Reis, Rui M.; Sousa, NunoDespite much effort to improve treatments, patients with malignant glioma still present a very poor prognosis that has not changed significantly in the last decades. In this context, it is crucial to better understand glioma pathogenesis to identify new molecular prognostic subgroups and therapeutic targets. WNT6 was recently identified as a new oncogenic molecule in glioblastoma (GBM), with prognostic value in...
The long non-coding RNA HOTAIR is transcriptionally activated by HOXA9 and is a...
Xavier-Magalhães, Ana; Gonçalves, Céline S; Fogli, Anne; Lourenço, Tatiana; Pojo, Marta; Pereira, Bruno; Rocha, Miguel; Lopes, Maria CelesteThe lncRNA HOTAIR has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of HOTAIR in glioma, the most common primary brain tumors, and its clinical relevance. HOTAIR gene expression, methylation, copy-number and prognostic value were investigated in human gliomas integrating data from online datasets and our cohorts. High levels of HOTAIR w...
WNT6 is a novel oncogenic prognostic biomarker in human glioblastoma
Gonçalves, Céline S.; Castro, Joana Isabel Martins Cosme Vieira; Pojo, Marta; Martins, Eduarda P.; Queirós, Sandro Filipe Monteiro; Chautard, EmmanuelGlioblastoma (GBM) is a universally fatal brain cancer, for which novel therapies targeting specific underlying oncogenic events are urgently needed. While the WNT pathway has been shown to be frequently activated in GBM, constituting a potential therapeutic target, the relevance of WNT6, an activator of this pathway, remains unknown. Methods: WNT6 protein and mRNA levels were evaluated in GBM. WNT6 levels were...
A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initia...
Pojo, Marta; Gonçalves, Céline S.; Magalhães, Ana Xavier; Oliveira, Ana Isabel; Gonçalves, Tiago; Correia, Sara; Rodrigues, Ana JoãoGlioblastoma is the most malignant brain tumor, exhibiting remarkable resistance to treatment. Here we investigated the oncogenic potential of HOXA9 in gliomagenesis, the molecular and cellular mechanisms by which HOXA9 renders glioblastoma more aggressive, and how HOXA9 affects response to chemotherapy and survival. The prognostic value of HOXA9 in glioblastoma patients was validated in two large datasets from...
The tumoral A genotype of the MGMT rs34180180 single-nucleotide polymorphism in...
Fogli, Anne; Chautard, Emmanuel; Vaurs-Barrière, Catherine ; Pereira, Bruno ; Müller-Barthélémy, Mélanie ; Court, Franck; Biau, JulianMalignant gliomas are the most common primary brain tumors. Grade III and IV gliomas harboring wild-type IDH1/2 are the most aggressive. In addition to surgery and radiotherapy, concomitant and adjuvant chemotherapy with temozolomide (TMZ) significantly improves overall survival (OS). The methylation status of the O-6-methylguanine-DNA methyltransferase (MGMT) promoter is predictive of TMZ response and a progno...