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Clinical characteristics and diagnostic accuracy of the revised Addenbrooke Cog...
Tavares-Júnior, José Wagner Leonel; Braga-Neto, Pedro; Bonfadini, Janine de Carvalho; Bittencourt, Lays; Lopes, Candida Helena; Mendes, LarissaObjective: To determine the diagnostic accuracy of the Addenbrooke’s Cognitive Examination Revised (ACE-R) as a cognitive screening tool for older adults with low levels of schooling and healthy aging, MCI and dementia in Brazil. Methods: All participants underwent neurological and psychiatric examinations and were administered a validated version of ACE-R. Results: A total of 85 participants were evaluated; mo...
Assessing the management of excessive daytime sleepiness by napping benefits
Murillo-Rodríguez, Eric; Yamamoto, Tetsuya; Monteiro, Diogo; Budde, Henning; Rocha, Nuno Barbosa; Cid, Luis; Teixeira, Diogo S.; Telles-Correia, DiogoPurpose Demanding lifestyle characterized by extended working hours, shift work schedules as well as excessive use of mobile gadgets leads to the disruption of the circadian and homeostatic factors affecting the sleep quality of individuals. As consequence, subjects complain of suffering several sleep disorders some of them characterized by inducing excessive daytime sleepiness (EDS). Currently, the therapeutic...
The Endocannabinoid System May Modulate Sleep Disorders In Aging
Murillo-Rodríguez, Eric; Budde, Henning; Veras, André Barciela; Rocha, Nuno Barbosa; Telles-Correia, Diogo; Monteiro, Diogo; Cid, LuisAging is an inevitable process that involves changes along life in multiple neurochemical, neuroanatomical, hormonal systems, and many others. In addition, these biological modifications lead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative disorders, and sleep disturbances, among others that affect activities of daily life. Demographic projections have dem...
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle...
Murillo-Rodríguez, Eric; Millán-Aldaco, Diana; Arankowsky-Sandoval, Gloria; Yamamoto, Tetsuya; Cid, Luis; Monteiro, Diogo; Rocha, Nuno BarbosaRationale The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARα. While the activation of PPARα by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown. Objectives We investigated the effects of bexarot...
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle...
Murillo-Rodríguez, Eric; Millán-Aldaco, Diana; Arankowsky-Sandoval, Glória; Yamamoto, Tetsuya; Cid, Luís; Monteiro, Diogo; Rocha, NunoThe nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARα. While the activation of PPARα by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown.
Assessing the management of excessive daytime sleepiness by napping benefits
Murillo-Rodríguez, Eric; Yamamoto, Tetsuya; Monteiro, Diogo; Budde, Henning; Rocha, Nuno; Cid, Luis; Teixeira, Diogo S.; Telles-Correia, DiogoPurpose Demanding lifestyle characterized by extended working hours, shift work schedules as well as excessive use of mobile gadgets leads to the disruption of the circadian and homeostatic factors affecting the sleep quality of individuals. As consequence, subjects complain of suffering several sleep disorders some of them characterized by inducing excessive daytime sleepiness (EDS). Currently, the therapeutic...
The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle...
Murillo-Rodríguez, Eric; Millán-Aldaco, Diana; Arankowsky-Sandoval, Gloria; Yamamoto, Tetsuya; Cid, Luis; Monteiro, Diogo; Rocha, Nuno BarbosaRationale: The nuclear receptor retinoid X receptor (RXR) belongs to a nuclear receptor superfamily that modulates diverse functions via homodimerization with itself or several other nuclear receptors, including PPARα. While the activation of PPARα by natural or synthetic agonists regulates the sleep-wake cycle, the role of RXR in the sleep modulation is unknown. Objectives: We investigated the effects of bexar...
The endocannabinoid system may modulate sleep disorders in aging
Murillo-Rodríguez, Eric; Budde, Henning; Veras, André Barciela; Rocha, Nuno; Telles-Correia, Diogo; Monteiro, Diogo; Cid, Luis; Yamamoto, TetsuyaAging is an inevitable process that involves changes across life in multiple neurochemical, neuroanatomical, hormonal systems, and many others. In addition, these biological modifications lead to an increase in age-related sickness such as cardiovascular diseases, osteoporosis, neurodegenerative disorders, and sleep disturbances, among others that affect activities of daily life. Demographic projections have de...
Blueberry intake included in hypocaloric diet decreases weight, glucose, choles...
Higuera-Hernández, María Fernanda; Reyes-Cuapio, Elena; Gutiérrez-Mendoza, Marissa; Budde, Henning; Blanco-Centurión, Carlos; Veras, André BarcielaObesity is a disease characterized by an excessive accumulation of fat in the body and it has been linked the enhancement of inflammation-related endogenous molecules, such as adenosine (AD). Since blueberries may induce anti-obesity effects, we tested the hypothesis that blueberries consumption contained in hypocaloric diet would decrease weight, BMI as well as glucose, cholesterol, triglycerides and AD levels...
Sleep and Neurochemical Modulation by DZNep and GSK-J1: Potential Link With His...
Murillo-Rodríguez, Eric; Arankowsky-Sandoval, Gloria; Barros, Jorge Aparecido; Rocha, Nuno Barbosa; Yamamoto, Tetsuya; Machado, Sérgio; Budde, HenningHistone methylation/demethylation plays an important modulatory role in chromatin restructuring, RNA transcription and is essential for controlling a plethora of biological processes. Due to many human diseases have been related to histone methylation/demethylation, several compounds such as 3-deazaneplanocin A (DZNep) or 3-((6-(4,5-Dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propan...