56 documents found, page 1 of 6
Formação de Equipas enquanto Estratégia de Retenção para Profissionais de Saúde...
Galamba, Sandra; Cerdeira, Raquel Mendes; Vicente, Cátia; Pinto, Carla; Poeira, Ana FilipaEnquadramento: A escassez global de profissionais de saúde torna emergente a sua retenção para garantir uma cobertura de saúde eficaz. A rotatividade externa dos profissionais de saúde constitui um desafio, com potenciais consequências para as organizações, os utentes e os próprios profissionais Objetivo: Verificar se a participação num programa de formação de equipas está associada com a intenção de rotativida...
Breastfeeding and malocclusions: Characterization of a pediatric dentistry popu...
Marques, Sofia Cameron; Baptista, Manuel; Magalhães, Inês; Morais, Juliana; Ferreira, Ana Filipa; Pestana, Rebeca; Jerónimo, Maria Luís; Pinto, CarlaBreastfeeding plays an important role in the development of the craniofacial complex (1,2). However, the role of breastfeeding duration, non-nutritive sucking habits, and the timing of solid food introduction on the development of malocclusions is still in debate (25). Therefore, this study aimed to investigate these associations in a birth cohort. In the ongoing OralBioBorn birth cohort, occlusion of three-yea...
Association between maternal cardiometabolic risk factors and oral health of in...
Pestana, Rebeca Saad; Baptista, Manuel; Magalhães, Inês; Morais, Juliana; Ferreira, Ana Filipa; Marques, Sofia Cameron; Jerónimo, Maria LuísMaternal health conditions during pregnancy influence infant health1-3. Cardiometabolic risk factors (CRFs), such as obesity, hypertension, and gestational diabetes, increase maternal and neonatal complications due to chronic inflammation, which disrupts immune and endocrine adaptation4,5. While the effects of CRFs on infant development are well studied, their impact on oral health remains unclear. Therefore, t...
TGFβ in malignant canine mammary tumors: relation with angiogenesis, immunologi...
Carvalho, Maria Isabel; Carvalho, Ricardo Emanuel Silva; Prada, Justina; Pinto, Carla; Gregório, Hugo; Lobo, Luis; Pires, Isabel; Queiroga, Felisbina L.Transforming growth factor- (TGF) and FoxP3 regulatory T cells (Treg) are involved in human breast carcinogenesis. This topic is not well documented in canine mammary tumors (CMT). In this work, the tumoral TGF expression was assessed by immunohistochemistry in 67 malignant CMT and its correlation to previously determined FoxP3, VEGF, and CD31 markers and other clinicopathologic parameters was evaluated. The hi...
Análise de variantes no gene STK11 e sua influência na resposta à imunoterapia
Bessa, Ana; Pina, Maria; Domigues, Patrícia; Dias, Margarida; Pinto, Carla; Cirnes, Luís; Silva, ReginaIntrodução: A imunoterapia é uma das ferramentas terapêuticas de sucesso usadas no tratamento do cancro de pulmão, contudo alguns doentes apresentam progressão da doença ou morte. O gene Serine/ threonine Kinase 11 (STK11) está descrito como tendo um papel na fisiologia do sistema imune (SI) e que alterações genéticas no mesmo podem influenciar negativamente a resposta dos pacientes à imunoterapia [1]. Objetivo...
Genotype-first approach to identify associations between CDH1 germline variants...
Garcia-Pelaez, José; Barbosa-Matos, Rita; Lobo, Silvana; Dias, Alexandre dos Santos; Garrido, Luzia; Castedo, Sérgio; Sousa, SóniaBackground Truncating pathogenic or likely pathogenic variants of CDH1 cause hereditary diffuse gastric cancer (HDGC), a tumour risk syndrome that predisposes carrier individuals to diffuse gastric and lobular breast cancer. Rare CDH1 missense variants are often classified as variants of unknown significance. We conducted a genotype– phenotype analysis in families carrying rare CDH1 variants, comparing cancer s...
FROM LEARNING MANAGEMENT SYSTEMS TO PERSONAL LEARNING ENVIRONMENTS: A PATH TO T...
Cruz, Mário; Queirós, Ricardo; Mascarenhas, Daniela; Pinto, CarlaThis article assumes that Learning Management Systems (LMS), such as Moodle or Blackboard, cannot respond to the current needs of our learners and fail to create bridges with Web 3.0. As such, through a literature review, we will seek on the one hand, to reflect on the need to resort to the Reflective and Participatory Approach to Design (RAPAD) methodology and the creation of Personal Learning Environments (PL...
ADAPTATION OF THE COURSE EXPERIENCE QUESTIONNAIRE TO A PORTUGUESE HIGHER EDUCAT...
Afonso, Luís; Mendonça, Jorge; Pinto, Carla; Babo, LurdesThe Course Experience Questionnaire has emerged in Australia, in 1981, to evaluate the teaching quality of certain degree programs. Since then, it has been applied in different countries and Higher Education Institutions (HEIs). In this work, the original questionnaire, consisting of 36 Likert-scale questions, was reproduced at Moodle, and data was gathered from 84 respondents. The sample was taken from the pop...
Análise de variantes no gene STK11 e sua influência na resposta à imunoterapia
Bessa, Ana; Pina, Maria; Domingues, Patrícia; Dias, Margarida; Pinto, Carla; Cirnes, Luís; Silva, Regina A.A imunoterapia é uma das ferramentas terapêuticas de sucesso usadas no tratamento do cancro de pulmão, contudo alguns doentes apresentam progressão da doença ou morte. O gene Serine/ threonineKinase 11 (STK11) está descrito como tendo um papel na fisiologia do sistema imune(SI) e que alterações genéticas no mesmo podem influenciar negativamente a resposta dos pacientes à imunoterapia. Estudar alterações genétic...
Frequency of CDH1, CTNNA1 and CTNND1 germline variants in families with diffuse...
Guerra, Joana; Pinto, Carla; Pinto, Pedro; Pinheiro, Manuela; Santos, Catarina; Peixoto, Ana; Escudeiro, Carla; Barbosa, Ana; Porto, MiguelHereditary diffuse gastric cancer (HDGC) is caused by germline pathogenic variants in the CDH1 and CTNNA1 genes and is characterized by a high prevalence of diffuse gastric cancer and lobular breast cancer. We aimed to evaluate the contribution of CTNNA1 and CTNND1 germline variants to HDGC, as well as to compare the frequencies of CDH1 and CTNNA1 (and eventually CTNND1) germline variants between patients with ...