13 documents found, page 1 of 2
Anti-leishmania activity of extract and fractions from the stem and leaf of Mon...
Faria, Lara Vinha; Brígido, Heliton Patrick Cordovil; Bentaberry-Rosa, Alexandre Augusto; Correa-Barbosa, Juliana; Silva-Silva, João VictorThis study aimed to evaluate the anti-leishmania activity of extracts and fractions from stem and leaf of Montrichardia linifera against Leishmania amazonensis. The stem (EES) and leaf (EEL) extracts were obtained by maceration of powders with 96º GL alcohol. The extracts were subjected to exhaustive extraction using a reflux system and solvents of increasing polarity, obtaining 4 fractions for each extract: he...
Antimalarial potential of quinones isolated from plants: an integrative review
Gomes, Antonio Rafael Quadros; Brígido, Heliton Patrick Cordovil; Vale, Valdicley Vieira; Correa-Barbosa, Juliana; Percário, SandroAntimalarial treatment is often associated with the resistance developed by Plasmodium which generate ineffective drug treatment. Based on this, the search for therapeutic alternatives is necessary and urgent. This review intends to assess the antimalarial potential of quinones isolated from plants. The search for scientific articles was carried out on the CAPES Journal Portal (PPC), Virtual Health Library (VHL...
Pharmacological activities and their relationship with the oxidative stress of ...
Gomes-Sousa, Nathália Cássia; Nunes, Lucas dos Santos; Martins, Hanna Patrícia dos Santos; Percário, Sandro; Dolabela, Maria FâniThe present work made an analysis of pharmacological studies of Morinda citrifolia L. and the role of oxidative stress. The research was carried out on the Capes and PubMed Journals Portal. Initially, titles, abstracts were read and those that had no relation to the topic and in duplicate were excluded. After this process, the works were read in full and the information was extracted. A total of 517 articles we...
Strategies used for the prevention and treatment of Burnout Syndrome
Lima, Suiane dos Santos Fialho de; Dolabela, Maria FâniObjective: This study carried out an integrative review in order to identify the prevention and treatment of Burnout syndrome, as well as to analyze the response of this strategy. Methodology: A search was carried out on the journals portal, using the following descriptor-treatment and burnout., 73 abstracts were selected for reading and at the end 18 articles were included. Results: To prevent and treat Burnou...
Anti-malarial activity and toxicity of Aspidosperma nitidum Benth: a plant used...
Brandão, Dayse Lucia do Nascimento; Martins, Michel Tavares; Silva, Adreanne Oliveira; Almeida, Amanda Dias; Paula, Renata Cristina deThe objective of this work was to evaluate the antiplasmodial activity and toxicity of the extract and fractions obtained from the bark of Aspidosperma nitidum. The ethanol extract obtained from the powdered bark of plants was acid-base partitioned and phytochemically analyzed. The antiplasmodial activity, in vivo antimalarial activity and in vitro cytotoxicity were acessed. The selectivity index (SI) was calcu...
Antitumor activity of Apocynaceae species used in Amazon traditional medicine
Bastos, Mirian Letícia Carmo; Sarmento, Rosana Moura; Bahia, Marcelo de Oliveira; Rodrigues, Jaqueline da Silva; Vale, Valdicley VieiraThis study reviews the use of Apocynaceae species for cancer and tumor treatment in the Amazon. Databases and books were searched for ethnobotanical and phytochemical evaluations of the cytotoxic and anticancer activities of Apocynaceae species. The literature reports the use of several Amazonian species, such as Asclepias curassavica, Himatanthus articulates, and Macoubea sprucei, in treating tumors and cancer...
Contributions of complementary therapies and other strategies to the treatment ...
Cruz, Liliane Oliveira; Almeida, Marcela Kelly Costa; Dolabela, Maria FâniThis study is an integrative literature review about complementary therapies and other strategies to treat schizophrenia. The search was carried out in the Virtual Health Library, CAPES, PUBMED and Cocrhane databases, with the descriptor “complementary medicine for schizophrenia”. We considered in this review publications between 2015 and 2020, written in Portuguese, English or Spanish. After applying all inclu...
In silico study of diperpens isolated from Portulaca pilosa L and their correla...
Brandão, Dayse Lúcia do Nascimento; Martins, Hanna Patricia dos Santos; Tomaz, Jéssica Melissa Oliveira; Ferreira, Gleison GonçalvesThis study reports the results obtained in the in silico study for the prediction of biological activity of diterpenes present in P. pilosa, relating these results to use claims, pharmacokinetic and toxicological aspects. Several programs were used to predict biological activities, toxicity, pharmacokinetics and physical chemical properties. Prediction studies suggest that healing activity was related to friede...
Prediction of pharmacokinetic behavior, toxicity and biological activities of a...
Ferreira, Gleison Gonçalves; Brandão, Dayse Lúcia do Nascimento; Dolabela, Maria FâniThis study predicted by in silico methods with the objective of predicting the pharmacokinetic behavior, toxicological and biological activities of alkaloids isolated from Geissospermum laeve. The designs of the molecules and physical-chemical analyzes were made at ChemSketch and Chemicalize.org, the pharmacokinetic behavior and toxicity were made by comparison in the PreADMET and PASS programs online. The resu...
In silico study of the activities of isolated compounds of Bauhinia variegata Linn
Nunes, Lucas dos Santos; Gomes, Jayanne Lilian Carvalo; Martins, Hanna Patrícia dos Santos; Dolabela, Maria FâniBauhinia variegata Linn belongs to the Fabaceae family and is popularly used as a hypoglycemic agent. Phytochemical studies isolated flavonoids, terpenes, steroids and naphthalene derivatives, and for this reason, this article aims to describe the results of pharmacokinetics, toxicity and biological activities obtained in in silico studies of the isolated molecules for B. variegata. The online databases for dat...