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Phytochemical analysis, antioxidant, antifungal activity, and genotoxicity of e...
Benoutman, Amina; Erbiai, El Hadi; Ettakifi, Hajar; Legssyer, Mounir; Handaq, Nadia; Makrane, Hanane; Saidi, Rabah; Lamrani, Zouhaire; Pintado, ManuelaTetraclinis articulata is a medicinal plant commonly known in Morocco as” Araar Tree “. Various parts of T. articulata are traditionally used for various therapeutic purposes. In this context, the present study aims to evaluate the antioxidant, antifungal, and genotoxicity of methanolic (TaLME), acetonic (TaLAE) extracts, and essential oil (TaLEO) from Tetraclinis articulata leaves growing in northern Morocco. ...
A cyclam salt as an antifungal agent: Interference with Candida spp. and Crypto...
Cerqueira, Fátima; Medeiros, Rui; Lopes, Inês; Campos, Carla; Ferraz, Maria Pia; Silva, Fernando; Alves, Luís G.; Pinto, EugéniaThe importance of fungal infections, particularly those caused by yeasts, is increasing among the medical community. Candida albicans and Cryptococcus neoformans are amongst the high-priority fungal species identified by the World Health Organization (WHO) and are considered in the critical group, while Candida krusei is included in the medium-priority group. The cyclam salt H4[H2(4-CF3PhCH2)2Cyclam]Cl4 proved ...
Carotenoids from cyanobacteria modulate iNOS and inhibit the production of infl...
Morone, Janaína; Vasconcelos, Vitor; Hentschke, Guilherme; Rosário Martins, Maria; Pinto, Eugénia; Lopes, GracilianaCyanobacteria are green multiproduct refineries of increasing interest for different industrial prospects. In this work, eleven cyanobacteria strains isolated from the Cape Verde archipelago were explored for their biotechnological applications in the field of inflammation. A biorefinery approach was employed to produce carotenoidtargeted extracts, further profiled by HPLC-PDA and explored for their ability to ...
Disclosing the antifungal mechanisms of the Cyclam Salt H4[H2(4-CF3PhCH2)2Cycla...
Costa, Inês; Lopes, Inês; Morais, Mariana; Silva, Renata; Remião, Fernando; Medeiros, Rui; Alves, Luís G.; Pinto, Eugénia; Cerqueira, FátimaMycoses are one of the major causes of morbidity/mortality among immunocompromised individuals. Considering the importance of these infections, the World Health Organization (WHO) defined a priority list of fungi for health in 2022 that include Candida albicans as belonging to the critical priority group and Pichia kudriavzevii (Candida krusei) to the medium priority group. The existence of few available antifu...
Pulmonary arterial hypertension with features of venous involvement: a detectiv...
Cazeiro, Daniel; Plácido, Rui; Azaredo Raposo, Miguel; Brito, Joana; Borba, Alexandra; Guimarães, Tatiana; Pinto, Eugénia; Freitas, PedroPulmonary veno-occlusive disease (PVOD) and pulmonary capillary hemangiomatosis are rare types of histopathological substrates within the spectrum of pulmonary arterial hypertension (PAH) with a very poor prognosis. They are characterized by a widespread fibroproliferative process of the small caliber veins and/or capillaries with sparing of the larger veins, resulting in a pre-capillary pulmonary hypertension ...
Synergistic anti-bacterial activity of imidazole-based azo dyes with polyvinylp...
Ribeiro, Ana Isabel Ferreira; Dantas, Daniela Filipa Costa; Carvalho, Luís Filipe; Padrão, Jorge; Silva, Renata; Remião, Fernando; Pinto, EugéniaThe high demand for novel antimicrobial textiles by the medical, healthcare, hygiene, sportswear, personal protective equipment, and filtration sectors promoted the growth of functional textiles. However, the efficacy of antimicrobial agents against different pathogens is a considerable challenge due to the distinctive mechanisms of action and resistance. The development of novel synergistic antimicrobial dyes ...
Vertical transmission and antifungal susceptibility profile of yeast isolates f...
Azevedo, Maria João; Araújo, Ricardo; Campos, Joana; Campos, Carla; Ferreira, Ana Filipa; Falcão-Pires, Inês; Ramalho, Carla; Zaura, EgijaYeast acquisition begins at birth; however, the contribution of the mother on yeast trans mission to the offspring and associated resistance is yet to be clarified. The aim of this study was to explore the vertical transmission of yeasts and their antifungal susceptibility profile in early life. Oral, fecal, and breastmilk samples were collected from 73 mother–child pairs four to twelve weeks after delivery and...
Halochromic silk fabric as a reversible pH-sensor based on a novel 2-aminoimida...
Ribeiro, Ana Isabel; Vieira, Bárbara Marques; Alves, Cátia Sofia Pereira; Silva, Bárbara; Pinto, Eugénia; Cerqueira, Fátima; Silva, RenataTextiles are important components for the development of lightweight and flexible displays useful in smart materials. In particular, halochromic textiles are fibrous materials with a color-changing ability triggered by pH variations mainly based on pH-sensitive dye molecules. Recently, a novel class of 2-aminoimidazole azo dyes was developed with distinct substituent patterns. In this work, silk fabric was func...
Synergistic antimicrobial activity of silver nanoparticles with an emergent cla...
Ribeiro, Ana Isabel Ferreira; Vieira, Bárbara Marques; Dantas, Daniela Filipa Costa; Silva, Bárbara; Pinto, Eugénia; Cerqueira, Fátima; Silva, Renatahe combination of two or more agents capable of acting in synergy has been reported as a valuable tool to fight against pathogens. Silver nanoparticles (AgNPs) present a strong antimicrobial action, although their cytotoxicity for healthy cells at active concentrations is a major concern. Azoimidazole moieties exhibit interesting bioactivities, including antimicrobial activity. In this work, a class of recently...
Red-shifted and pH-responsive imidazole-based Azo Dyes with potent antimicrobia...
Dantas, Daniela Filipa Costa; Ribeiro, Ana Isabel Ferreira; Carvalho, Filipe; Gil-Martins, Eva; Silva, Renata; Remião, Fernando; Zille, AndreaA novel route is described to obtain 2 aminoimidazole azo dyes with unique substituents pattern in the heteroaryl unit that provides halochromic properties, exhibiting vibrant colours that change from magenta to deep blue. Potent antimicrobial properties against infectious yeasts were demonstrated. No cytotoxicity was detected for concentrations lower than 16 μg·mL-1