28 documents found, page 1 of 3

Consumer-controlled digital twin architecture: How blockchain technology gives ...

This article presents Consumer-Controlled Digital Twin Architecture (C2DTA), a novel architecture that aims to empower consumers in the Personal Data Ecosystem (PDE). The hallmark of the architecture is the transfer of the smart device Digital Twin (DT) to the consumer domain, granting consumers de facto control over their data. This paradigm shift hinges on multiple decentralized technologies, chiefly Self-Sov...

Quercetin-1,2,3-Triazole Hybrids as Multifunctional Anti-Alzheimer's Agents

The number of patients with Alzheimer’s disease (AD) continues to rise and, despite the efforts of researchers, there are still no effective treatments for this multifaceted disease. The main objective of this work was the search for multifunctional and more effective anti-Alzheimer agents. Herein, we report the evaluation of a library of quercetin-1,2,3-triazole hybrids (I–IV) in antioxidant, hydrogen peroxide...

People-centered Distributed Ledger Technology-IoT architectures: A systematic l...

To understand how distributed ledger technology (DLT) enables people-centered IoT solutions we conducted a systematic literature review of tested implementations since 2017. We created a people-centered classification to analyze 39 implementations. We found that people-centered DLT-IoT architectures are in their infancy and detected no evidence of emerging patterns. We observed that Ethereum is the most used DL...

Cost-effectiveness of cardio-oncology clinical assessment for prevention of che...

Introduction Cancer chemotherapy increases the risk of heart failure. This cost-effectiveness study analyzes cardio-oncology imaging assessment of left ventricular ejection fraction (LVEF) using a Portuguese healthcare payer perspective and a five-year time horizon. Methods Two cardioprotective strategies were assessed: universal cardioprotection (UCP) for all patients and cardioprotection initiated on diagnosi...

Familial Hypercholesterolemia study in dyslipidemic children and adolescents: “...

Aim: The _ompound_d_otic process begins in childhood and despite the estimated incidence of 1/500 in Portugal, Familial Hypercholesterolemia (FH) is one of the most underdiagnosed causes of accelerated atherosclerosis leading to premature cardiovascular death.

Brachyury oncogene is a prognostic factor in high-risk testicular germ cell tumors

The T-box transcription factor Brachyury has been considered a cancer-specific marker and a novel oncotarget in solid tumors. Brachyury overexpression has been described in various cancers, being associated with epithelial-mesenchymal transition, metastasis, and poor prognosis. However, its clinical association with testicular germ cell tumor is unknown. We analyzed the expression of Brachyury by immunohistoche...

Acidity reduction in animal fats by enzymatic esterification: economic and envi...

Atitudes do enfermeiro em contexto de ensino clínico: uma revisão da literatura

Com o decorrer do Ensino Clínico torna-se crucial compreender de que modo as atitudes dos enfermeiros influenciam o desempenho dos alunos. Cuidados de excelência só podem ser assegurados com a passagem de testemunho do Enfermeiro para o aluno. Nesta linha, as atitudes que os enfermeiros supervisores apresentam, tornam-se o “espelho” e o reflexo do futuro profissional. O supervisor tem a capacidade de melhorar a...

SPINT2 deregulation in prostate carcinoma

SPINT2 is a tumor suppressor gene that inhibits proteases implicated in cancer progression, like HGFA, hepsin and matriptase. Loss of SPINT2 expression in tumors has been associated with gene promoter hypermethylation; however, little is known about the mechanisms of SPINT2 deregulation in prostate cancer (PCa). We aimed to analyze SPINT2 expression levels and understand the possible regulation by SPINT2 promot...

OPI1P translocation to the nucleus is regulated through oxidation by hydrogen p...

Adaptation of yeast cells to hydrogen peroxide (H2O2) leads to a rapid change in membrane permeability accompanied by a decrease of membrane fluidity and the alteration of its lipid composition, allowing cells to survive to higher doses of H2O2. During adaptation to H2O2 several genes that contain the regulatory element UASINO, and which codify for enzymes involved in phospholipid and fatty acid metabolism, are...