2 documents found, page 1 of 1
Warfarin pharmacogenomics: Designing electrochemical DNA-based sensors to detec...
Barbosa, Tiago; Morais, Stephanie L.; Pereira, Eduarda; Magalhães, Júlia M. C. S.; Domingues, Valentina F.; Ferreira-Fernandes, Hygor; Pinto, GiovannyThe CYP2C9 enzyme is involved in the metabolism of warfarin. The CYP2C9 gene harbors several single-nucleotide polymorphisms (SNPs), including CYP2C9*2 (rs1799853), which is known to affect warfarin’s therapeutic response. So, it is important to develop analytical tools capable of genotyping these SNPs to adjust warfarin’s therapeutic outcomes. In this work, an electrochemical DNA-based sensor was constructed a...
mtDNA structure : the women who formed the Brazilian Northeast
Schaan, Ana Paula; Costa, Lorenna; Santos, Diego; Modesto, Antonio; Amador, Marcos; Lopes, Camile; Rabenhorst, Silvia Helena Barem; Montenegro, RaquelBackground: The distribution of mitochondrial DNA (mtDNA) lineages in Brazil is heterogeneous due to different regional colonization dynamics. Northeastern Brazil, although being an important region in terms of human imigration and ethnic admixture, has little information regarding its population mtDNA composition. Here, we determine which mitochondrial lineages contributed to the formation of the Northeastern ...