23 documents found, page 1 of 3

The Renal and Systemic Impact of Rituximabin Patients with Refractory Systemic ...

Lupus nephritis (LN), a severe complication of systemic lupus erythematosus (SLE), worsens the renal and vital prognosis for up to 50% of SLE patients. Standard treatment involves corticosteroids with cyclophosphamide (CyP) or mycophenolate mofetil (MMF), yet the refractory nature of some cases necessitates alternative therapies. Rituximab (RTX), an anti-CD20 monoclonal antibody, has shown potential in SLE by t...

Position Statement of the Immunonephrology Working Group of the Portuguese Soci...

Systemic lupus erythematosus (SLE) is a challenging immune ‑mediated disease that frequently involves the kidney as lupus nephritis (LN), an immune complex glomerulonephritis. Its occurrence is associated with increased morbidity and mortality and current treatment still fails to preserve renal function in the long term. As such, more efficacious and less toxic treatments are needed to treat LN, aiming to reduc...

Illness Stigma and Shame in People With Chronic Illnesses vs. SARS-CoV-2 Surviv...

Individuals with chronic illnesses and those infected with SARS-CoV-2 often face stigma, shame, and psychological distress related to their conditions. Higher psychological flexibility and self-compassion are often associated with less stigma and shame. Examining and comparing these experiences between people with chronic illness and people who have recovered from SARS-CoV-2 can provide valuable insights into t...

Real-World Experience with Avacopan in ANCA-Associated Vasculitis in Portugal

Introduction: Avacopan, a selective C5a receptor inhibitor, has emerged as a potential corticosteroid-sparing treatment in ANCA-associated vasculitis (AAV). This study aims to evaluate its real-world efficacy and safety in Portuguese patients with active AAV. Methods: We conducted a multicenter retrospective analysis of 15 adult patients with newly diagnosed or relapsing AAV treated with avacopan across nine ac...

The Critical Role of Multidisciplinary Teams inthe Management of Rare Systemic ...

Rare systemic rheumatic diseases (RISD) with renal involvement, such as anti‑neutrophil cytoplasmic antibody (ANCA)‑associated vasculitis and systemic lupus erythematosus, require complex, coordinated care. These conditions often involve renal complications requiring specialized and timely intervention. Traditional care models, typically fragmented across specialties, are insufficient to meet the nuanced needs ...

The use of manipulative materials for the development of number sense and calcu...

This study aimed to understand the impact of using manipulatives on the development of number sense and mental calculation in first-grade students. Conducted within an action-research framework, the study involved a class of 18 students over three weeks. The intervention consisted of a sequence of tasks using the ten-frame, bead string, and dot cards, promoting representation, decomposition, and problem-solving...

One-year predictors of PTSD symptoms, anxiety, and depression in SARS-CoV-2 sur...

Introduction: The COVID-19 pandemic held considerable health-related outcomes worldwide, including mental health challenges, with elevated risk of psychiatric sequelae. Methods: This study aimed to test the longitudinal (1 year) predictive role of psychosocial factors on post-traumatic stress disorder (PTSD), anxiety, and depressive symptoms in SARS-CoV-2 survivors (N = 209 at T1; N = 61; attrition rate 70.83%)...

Illness Stigma and Shame in People with Chronic Illnesses vs. SARS-CoV-2 Surviv...

Individuals with chronic illnesses and those infected with SARS-CoV-2 often face stigma, shame, and psychological distress related to their conditions. Higher psychological flexibility and self-compassion are often associated with less stigma and shame. Examining and comparing these experiences between people with chronic illness and people who have recovered from SARS-CoV-2 can provide valuable insights into t...

When Kidney Mirrors the Eye: Tubulointerstitial Nephritis and Uveitis Syndrome ...

Tubulointerstitial nephritis and uveitis syndrome is an underdiagnosed condition, characterized by the involvement of the kidney and the eye that affects mostly young people. Its pathophysiology remains poorly understood; however, pediatric morbidity is mostly associated with recurrences of uveitis. This article aimed to describe two clinical cases of tubulointerstitial nephritis and uveitis syndrome, with dist...

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