4 documents found, page 1 of 1
Interleukin-6 gene -174G>C and -636G>C promoter polymorphisms and prostate canc...
Magalhães, J. F.; Cortinhas, A. J.; Albuquerque, C. M.; Baptista, C. S.; Ribeiro, R.; Viegas, Carlos A.; Matos, Augusto; Machado, João; Pires, Maria A.Prostate cancer (PCa) is one of the most commonly diagnosed internal malignancies affecting men. Due to the important roles of IL-6 in different physiological and pathophysiological processes,IL-6polymorphisms may modulate PCa risk.IL-6−174 G>C (rs 1800795, also designated −236 G>C) and −636 G>C (rs 1800796, also designated −572 G>C) promoter polymorphisms have been implicated in PCa susceptibility, albeit stil...
Canine periodontitis : the dog as an important model for periodontal studies
Albuquerque, Carlos; Morinha, Francisco; Requicha, João; Martins, Teresa Maria; Dias, Isabel R.; Pinto, Henrique Guedes; Bastos, EstelaPeriodontal disease (PD) refers to a group of inflammatory diseases caused by bacterial plaque in the periodontium and ranges from an early stage (gingivitis) to an advanced stage (periodontitis). It is a multifactorial disease that results from the interaction of the host defence mechanisms with the plaque microorganisms. Early detection, diagnosis and treatment are essential in the control of this disease. PD...
Detection and characterization of interleukin-6 gene variants in canis familiar...
Morinha, Francisco; Albuquerque, Carlos; Requicha, João; Dias, Isabel R.; Leitão, José; Gut, Ivo; Pinto, Henrique Guedes; Viegas, Carlos A.Periodontal disease (PD) is the most common inflammatory disease of the oral cavity of domestic carnivores. In Human Medicine molecular genetics research showed that several genes play a role in the predisposition and progression of this complex disease, primarily through the regulation of inflammatory mediators, but the exactly mechanisms are poorly understood. This study aims to contribute to the characteriza...
The Institute for Biotechnology and Bioengineering (IBB)
Cabral, J. M. S.; Mota, M.; Reis, R. L.; Pinto, Henrique Guedes; Martel, Paulo; Ferreira, Guilherme; Ferreira, Eugénio C.The Laboratório Associado Institute for Biotechnology and Bioengineering (IBB) is a research unit aiming to be a strategic infrastructure for the development of the Portuguese R&D and innovation policies in the areas of Biotechnology, Bioengineering, Biomaterials and Life, Biomedical and Agricultural Sciences. IBB combines its R&D activities with advanced higher education, technology transfer, consulting and se...