6 documents found, page 1 of 1
A comunicação das marcas de moda através das redes sociais: a perceção dos cons...
Pinto, Inês MendesO presente estudo tem como tema central a perceção do consumidor perante a comunicação das marcas de moda nas redes sociais. Com a internet, tudo se tornou mais rápido e facilitado e, como tal, o comportamento dos consumidores de moda sofreu algumas alterações. Consequentemente, as redes sociais tornaram-se um dos canais essenciais de comunicação para as marcas de moda. As possibilidades tornam-se infinitas no ...
Microglial Rac1 is essential for experience-dependent brain plasticity and cogn...
Socodato, Renato; Almeida, Tiago O.; Portugal, Camila C.; Santos, Evelyn C.S.; Tedim-Moreira, Joana; Ferreira, João Galvão; Canedo, TeresaMicroglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the RhoGTPase Rac1 is an essential requirement for microglia to sense and interpret the brain microenvironment. This is crucial for microglia-synapse crosstalk that drive...
MSC morphofunctional programming for improved orthopaedic implantation outcomes
Fonseca, Francisca Rocha Melo; Pinto, Inês Mendes; Gasik, Michael; Silva, Filipe Samuel; Miranda, Maria Georgina MacedoOrthopaedic interventions have risen over the last two decades and are expected to increase due to aging population. Despite advances in orthopaedic implant research, prosthetic failure is often observed, leading to implant replacement. Impaired implant fixation is mainly due to an improper mechanical stimulation at the interface between natural bone and the implant, often composed of Ti6Al4V. At the cellular l...
Improving the interface between orthopaedic implants and bone - a comparison be...
Fonseca, Francisca Rocha Melo; Gasik, Michael; Pinto, Inês Mendes; Madeira, Sara Cristina Soares; Silva, Filipe Samuel; Miranda, Maria Georgina MacedoOrthopedic implants for load-bearing applications are usually composed of titanium-based materials. However, insufficient bioactivity of metallic materials impairs the bonding with bone, compromising osseointegration at an early stage. The implant-bone interface may be improved by regulating some surface properties of the biomaterials, including surface chemical composition, surface energy, roughness and topogr...
Timely and Blood-Based Multiplex Molecular Profiling of Acute Stroke
Dias, Alexandre; Silva, Isabel; Pinto, Inês Mendes; Maia, LuisStroke is a leading cause of death and disability in the world. To address such a problem, early diagnosis and tailored acute treatment represent one of the major priorities in acute stroke care. Since the efficacy of reperfusion treatments is highly time-dependent, there is a critical need to optimize procedures for faster and more precise diagnosis. We provide a concise review of the most relevant and well-do...
Robust gap repair in the contractile ring ensures timely completion of cytokinesis
Silva, Ana M; Osório, Daniel S; Pereira, Antonio J; Maiato, Helder; Pinto, Inês Mendes; Rubinstein, Boris; Gassmann, Reto; Telley, Ivo AndreasCytokinesis in animal cells requires the constriction of an actomyosin contractile ring, whose architecture and mechanism remain poorly understood. We use laser microsurgery to explore the biophysical properties of constricting rings in Caenorhabditis elegans embryos. Laser cutting causes rings to snap open. However, instead of disintegrating, ring topology recovers and constriction proceeds. In response to sev...