64 documents found, page 1 of 7
Effect of plasticizer content on the processability of paroxetine-loaded filame...
Figueiredo, Sara; Fernandes, Ana Isabel; Henriques Dias Fernandes, Ana Isabel; Carvalho, Fátima G.; Pinto, João F.Poster presented at the 14th PBP World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Viena, Austria, 18-21 March 2024
Estudo de caso: otimização do fabrico de medicamentos impressos na Farmácia Com...
Figueiredo, Sara; Fernandes, Ana Isabel; Carvalho, Fátima G.; Pinto, João F.Poster apresentado no Congresso Nacional dos Farmacêuticos 2024. Lisboa, 21-23 Novembro 2024
Selection of hydroxypropylcellulose grade for paroxetine 3D printable formulati...
Figueiredo, Sara; Pinto, João F.; Carvalho, Fátima G.; Fernandes, A.I.
Impact of formulation of drug containing blends on 3D printing by fused deposit...
Fernandes, A.I.; Figueiredo, Sara; Carvalho, Fátima G.; Pinto, João F.
Preparation of medicines by three dimensional printing and personalization of t...
Figueiredo, Sara; Fernandes, A.I.; Cardoso, Nuno; Carvalho, Fátima G.; Pinto, João F.
Estudo de caso : otimização do fabrico de medicamentos impressos na farmácia co...
Figueiredo, Sara; Fernandes, A.I.; Carvalho, Fátima G.; Pinto, João F.
Downstream processing of amorphous and co-amorphous Olanzapine powder blends
Costa, Nuno F. da; Daniels, Rolf; Fernandes, Ana I.; Pinto, João F.The work evaluates the stability of amorphous and co-amorphous olanzapine (OLZ) in tablets manufactured by direct compression. The flowability and the compressibility of amorphous and co-amorphous OLZ with saccharin (SAC) and the properties of the tablets obtained were measured and compared to those of tablets made with crystalline OLZ. The flowability of the amorphous and mostly of the co-amorphous OLZ powders...
Sulfonic acid derivatives in the production of stable co-amorphous systems for ...
Costa, Nuno F. da; Santos, Inês A.; Fernandes, Ana I.; Pinto, João F."Co-amorphization is a promising approach to stabilize drugs in the amorphous form. Olanzapine, a poorly water-soluble drug was used in this study. Sulfonic acids (saccharin, cyclamic acid and acesulfame), free and in salt forms, were used as co-formers and compared with carboxylic acids commonly used in the preparation of co-amorphous systems. Several manufacturing techniques were tested, and the co-amorphous ...
In-situ co-amorphization of olanzapine in pellets
Azevedo, Raquel; Costa, Nuno F. da; Fernandes, Ana I.; Pinto, João F.
Amorphous and co-amorphous Olanzapine stability in formulations intended for we...
Costa, Nuno F. da; Daniels, Rolf; Fernandes, Ana I.; Pinto, João F.The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility and bioavailability issues of poorly water-soluble chemical entities. However, stress conditions imposed during common pharmaceutical processing (e.g., tableting) may cause the recrystallization of the systems, warranting close stability monitoring throughout production. This work aimed at assessing the water and h...