3 documents found, page 1 of 1
Tau-dependent suppression of adult neurogenesis in the stressed hippocampus
Dioli, Chrysoula; Patrício, P.; Trindade, R.; Pinto, L. G.; Silva, J. M.; Morais, M.; Ferreiro, E.; Borges, S.; Mateus-Pinheiro, A.; Rodrigues, A. J.Stress, a well-known sculptor of brain plasticity, is shown to suppress hippocampal neurogenesis in the adult brain; yet, the underlying cellular mechanisms are poorly investigated. Previous studies have shown that chronic stress triggers hyperphosphorylation and accumulation of the cytoskeletal protein Tau, a process that may impair the cytoskeleton-regulating role (s) of this protein with impact on neuronal f...
Injectable gellan gum hydrogels as supports for cartilage tissue engineering ap...
Oliveira, J. T.; Picciochi, R.; Santos, T. C.; Martins, L.; Pinto, L. G.; Malafaya, P. B.; Sousa, R. A.; Marques, A. P.; Castro, A. G.; Mano, J. F.Gellan gum is an extracellular microbial polysaccharide from Sphingomonas paucimobilis that forms a firm and transparent gel in the presence of metallic ions. This hydrogel presents some interesting features that allow its use as a cell encapsulating support, or as an in vivo injectable system. In this work, the usefulness of gellan gum hydrogels as supports for cartilage tissue engineering applications was sho...
Injectable gellan gum hydrogels as supports for cartilage tissue engineering ap...
Oliveira, J. T.; Picciochi, R.; Santos, T. C.; Martins, L.; Pinto, L. G.; Malafaya, P. B.; Sousa, R. A.; Marques, A. P.; Castro, A. G.; Mano, J. F.Gellan gum is an extracellular microbial polysaccharide from Sphingomonas paucimobilis that forms a firm and transparent gel in the presence of metallic ions. This hydrogel presents some in- teresting features that allow its use as a cell encapsulating support, or as an in vivo injectable system. In this work, the usefulness of gellan gum hydrogels as supports for cartilage tissue engineering applications was s...