3 documents found, page 1 of 1
Layered double hydroxide?indomethacin hybrid: A promising biocompatible compoun...
Meneses, Carla Carolina Ferreira; Sousa, Paulo Robson Monteiro; Pinto, Laine Celestino; Coelho, Gerson Maciel; Silva, Tamires Ferreira daFederal University of Par?. Institute of Exact and Natural Sciences. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Exact and Natural Sciences. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Bel?m, PA, Brazil.; Federal University of Par?. Institute of Biological Sciences. Bel?m, PA,...
Mebendazole induces apoptosis via C-MYC inactivation in malignant ascites cell ...
Pinto, Laine Celestino; Mesquita, Felipe Pantoja; Soares, Bruno Moreira; Silva, Emerson Lucena da; Puty, Bruna; Oliveira, Edivaldo Herculano Correa deFederal University of Par?. Biological Science Institute. Laboratory of Experimental Neuropathology. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development Center. Laboratory of Pharmacogenetics. Fortaleza, CE, Brazil.; Federal University of Par?. Biological Science Institute. Laboratory of Human Cytogenetics. Bel?m, PA, Brazil.; Federal University of Cear?. Drug Research and Development...
Synthesis and biological evaluation of novel 6-Hydroxy-benzo[d][1,3]oxathiol-2-...
Chazin, Eliza de Lucas; Sanches, Paola de Souza; Lindgren, Eric Brazil; Vellasco Júnior, Walcimar Trindade; Pinto, Laine CelestinoWith the aim of discovering new anticancer agents, we have designed and synthesized novel 6-hydroxy-benzo[d][1,3]oxathiol-2-one Schiff bases. The synthesis started with the selective nitration at 5-position of 6-hydroxybenzo[d][1,3]oxathiol-2-one (1) leading to the nitro derivative 2. The nitro group of 2 was reduced to give the amino intermediate 3. Schiff bases 4a–r were obtained from coupling reactions betwe...