57 documents found, page 1 of 6
Pregnancy outcomes in systemic sclerosis: experience of a rheumatology-obstetri...
Chícharo, Ana Teodósio; Lopes, Ana Rita; Barreira, Sofia; Martins, Patrícia; Machado, Ana Rita Cruz; Pinto, Luísa; Capela, SusanaSystemic sclerosis (SSc) is a rare multisystemic connective tissue disease (CTD). It is mainly characterized by progressive fibrosis and non-inflammatory vasculopathy. Women diagnosed with SSc seem to be at increased risk of developing adverse pregnancy outcomes (APO), but maternal and perinatal outcomes remain poorly understood in these patients, with no data yet available from Portuguese centers.
Concordância e Diferença. 'Liber Amicorum' para João Maria André
Carvalho, Mário Santiago de; Oliveira, Fernando Matos; Souza, Klédson Tiago Alves de; Neto, José Teixeira; Rusconi, María Cecilia; D'Amico, Claudia'Concordância e Diferença' festeja a vida ativa do filósofo e professor João Maria André, acolhendo testemunhos e gestos de quem o conhece, admira e com quem ele privou ao longo de muitos anos de viva amizade. É convicção de todas as autoras e autores, reunidos em torno deste volume de agradecimento, que, ao longo destas páginas ressoa, numa abrangente tematização, a escuta, a hospitalidade e a capacidade refle...
Dual challenge inside the womb: a case report of concomitant fetal atrio-ventri...
Chícharo, Ana Teodósio; Rebelo, Mónica; Lopes, Ana Rita; Saavedra, Maria João; Paramés, Maria Filipa; Araújo, Ana Rita; Machado, Ana Rita CruzFetal autoimmune atrioventricular block (AVB) is a rare but potentially life-threatening condition. It results from the passage of maternal anti-SSA/Ro or Anti SSB/La auto-antibodies into the fetal circulation, leading to inflammation and fibrosis of the AV node and often to irreversible damage. Besides AVB, these antibodies can also cause cardiomyopathies, but there is no evidence linking them to tachyarrhythm...
Maternal and perinatal outcomes in pregnant women with rheumatic diseases treat...
Chícharo, Ana Teodósio; Lopes, Ana R.; Barreira, Sofia; Pinto, Luísa; Machado, Ana R. Cruz; Capela, SusanaNo safety or efficacy issues arose from using biosimilar TNFi during conception or pregnancy.
StressMatic: Bridging innovation and reliability in animal models of stress
Martins-Macedo, Joana; Gomes, Eduardo D.; Oliveira, João F.; Patrício, Patrícia; Pinto, Luísa; Gomes, EduardoPreclinical research involving animal models of stress exposure typically rely on traditional manual protocols, which are laborious and time-consuming and may compromise reproducibility and the effective translation of f indings into clinical applications. StressMatic is an automated stress exposure system (auCMS), designed to improve the standardization and reproducibility of stress-induction methodologies. Th...
Glial-restricted precursors stimulate endogenous cytogenesis and effectively re...
Martins-Macedo, Joana; Araújo, Bruna; Anjo, Sandra I.; Silveira-Rosa, Tiago; Patrício, Patrícia; Alves, Nuno Dinis; Silva, Joana M.; Teixeira, Fábio G.Adult cytogenesis, the continuous generation of newly-born neurons (neurogenesis) and glial cells (gliogenesis) throughout life, is highly impaired in several neuropsychiatric disorders, such as Major Depressive Disorder (MDD), impacting negatively on cognitive and emotional domains. Despite playing a critical role in brain homeostasis, the importance of gliogenesis has been overlooked, both in healthy and dise...
StressMatic: a novel automated system to induce depressive- and anxiety-like ph...
Martins-Macedo, Joana; Mateus-Pinheiro, António; Alves, Cátia; Veloso, Fernando José Silva; Gomes, Eduardo D.; Ribeiro, Inês; Correia, Joana S.Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...
Nephrotic syndrome in pregnant diabetic women: maternal and perinatal outcomes ...
Nogueira, Estela; Afonso, Rita; Godinho, Iolanda; Centeno, Mónica; Pinto, Luísa; Lopes, José AntónioManagement of pregnant women with diabetic kidney disease and nephrotic range proteinuria or nephrotic syndrome constitute a challenge to clinicians. Maternal and perinatal outcomes, especially in patients with chronic kidney disease, remain poor. The authors describe the multidisciplinary approach and the outcomes of diabetic pregnant patients with nephrotic range proteinuria.
The Duration of Stress Determines Sex Specificities in the Vulnerability to Dep...
Gaspar, Rita; Soares-Cunha, Carina; Domingues, Ana Verónica; Coimbra, Bárbara; Baptista, Filipa; Pinto, Luísa; Ambrósio, António; Rodrigues, Ana-JoãoStress exposure has been shown to induce a variety of molecular and functional alterations associated with anxiety and depression. Some studies suggest that microglia, the immune cells of the brain, play a significant role in determining neuronal and behavioral responses to chronic stress and also contribute to the development of stress-related psychopathologies. However, little is known about the impact of the...
Beyond new neurons in the adult hippocampus: imipramine acts as a pro-astroglio...
Machado-Santos, Ana R.; Loureiro-Campos, Eduardo; Patrício, Patrícia; Araújo, Bruna Alexandra Vale; Alves, Nuno Dinis; Mateus-Pinheiro, AntónioDepression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, l...