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Imipenem-Relebactam Susceptibility in Enterobacterales Isolates Recovered from ...

Hernández-García, M; García-Castillo, M; Bou, G; Cercenado, E; Delgado-Valverde, M; Oliver, A; Pitart, C; Rodríguez-Lozano, J; Tormo, N

Imipenem-relebactam is a novel β-lactam-β-lactamase inhibitor combination. We evaluated the in vitro activity of imipenem-relebactam and comparators against Enterobacterales clinical isolates recovered in 8 Spanish and 11 Portuguese intensive care units (ICUs) (SUPERIOR, 2016-2017; STEP, 2017-2018). Overall, 747 Enterobacterales isolates (378 Escherichia coli, 252 Klebsiella spp., 64 Enterobacter spp., and 53 o...


A Rare but Real Necessity: Case Report of Coronary Artery Stenting in an Infant

Martins, JD; Lourenço, G; Sousa, L; Pinto, MF

Percutaneous coronary intervention (PCI) is an extremely common and well-established procedure in adults which is rarely performed in children. We present a case of a successful left main coronary artery stenting in a small infant with a congenital coronary artery anomaly. We highlight the technical challenges of performing a PCI in a small patient, the risks of antithrombotic prophylaxis in this age group, and...


Cardiomyopathy. Like Mother, Like Daughter? A New Phenotype for a MYH7 Mutation

Abreu, S; Trigo, C; Pinto, MF

We report the case of a six-year-old girl referred to our department due to her mother's diagnosis of hypertrophic cardiomyopathy. Initial evaluation revealed restrictive physiology on echocardiography and cardiac catheterization. Genetic analysis of both mother and daughter revealed the same genetic variant at the MYH7 gene. Notably, although the genetic mutation was the same, the phenotype differed, resulting...


Iatrogenic Fistula Between the Aorta and the Right Ventricular Outflow Tract Af...

Loureiro, P; Martins, JF; Fraisse, A; Rodrigues, R; Fragata, J; Pinto, MF

We present the first case of an iatrogenic aorta to right ventricular outflow tract fistula after Melody valve implantation. A 11-year-old girl, born with tetralogy of Fallot with absent pulmonary valve, underwent surgical repair at three years old with a 15-mm homograft. At five years old, calcification and stenosis of the homograft prompted successful balloon angioplasty and five years later she underwent Mel...


A Very Rare Case of Coronary Artery Bypass Grafting in a Progeria Child

Cerejo, R; Rodrigues, R; Martins, JD; Torres, C; Sousa, L; Pinto, MF; Fragata, J

Hutchinson-Gilford progeria syndrome is a rare genetic disorder, characterized by progressive premature aging and early death in the first or second decade of life, usually secondary to cardiovascular events (myocardial infarction and stroke). We report a case of a 14-year-old boy with progeria syndrome and cardiac arrest due to myocardial infarction, who was submitted to an immediate coronary angiography which...



Prognostic Power of Anaerobic Threshold Parameters in Patients with Transpositi...

Valentim Gonçalves, A; Mano, T; Agapito, A; Aguiar Rosa, S; Sousa, L; Rio, P; Oliveira, JA; Monteiro, A; Pereira-da-Silva, T; Ilhão Moreira, R

INTRODUCTION: Both transposition of the great arteries (TGA) previously submitted to a Senning/Mustard procedure and congenitally corrected TGA (cc-TGA) have the systemic circulation supported by the morphological right ventricle, thereby rendering these patients to heart failure events risk. The aim of this study was to evaluate cardiopulmonary exercise test parameters for stratifying the risk of heart failure...


Pericarditis. Clinical Presentation and Characteristics of a Pediatric Population

Perez-Brandão, C; Trigo, C; Pinto, MF

INTRODUCTION: Pericarditis is an inflammation of the pericardium. It may be infectious or secondary to a systemic disease. The aim of this study was to analyze the clinical findings, course, treatment and follow-up of children diagnosed with pericarditis at our center. METHODS: We performed a retrospective analysis of all children admitted to our pediatric cardiology unit with pericarditis between 2003 and 2015...


RoPE Score As a Predictor of Recurrent Ischemic Events After Percutaneous Paten...

Morais, LA; Sousa, L; Fiarresga, A; Martins, JD; Timóteo, AT; Viveiros Monteiro, A; Soares, C; Agapito, A; Pinto, MF; Cruz Ferreira, R

The benefits of patent foramen ovale (PFO) closure for cryptogenic stroke secondary prevention are still debated. The Risk of Paradoxical Embolism (RoPE) study developed a score to improve patient selection for this procedure. We proposed to assess the validity of this score to assess the prognostic impact of PFO closure.From 2000 to 2014, all consecutive patients submitted to PFO closure were included in a pro...


Percutaneous Pulmonary Valve Implantation in Small Conduits: A Multicenter Expe...

Hascoet, S; Martins, JD; Baho, H; Kadirova, S; Pinto, MF; Paoli, F; Bitar, F; Haweleh, A; Uebing, A; Acar, P; Ghez, O; Fraisse, A

BACKGROUND: Guidelines allow percutaneous pulmonary valve implantation (PPVI) in conduits above 16mm diameter. Balloon dilatation of a conduit to a diameter>110% of the original implant size is also not recommended. We analyzed patients undergoing PPVI in such conditions. METHODS AND RESULTS: Nine patients (May 2008-July 2016) from 8 institutions underwent PPVI in conduits <16mm diameter. Five patients with 16-...


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