3 documents found, page 1 of 1
Subpial Hemorrhage : A Distinctive Neonatal Stroke Pattern
Pinto, C; Cunha, B; Pinto, MM; Conceição, CBackground and purpose: Subpial hemorrhage is a rare form of neonatal stroke, still poorly understood. The aim of this study was to characterize a cohort of term and preterm neonates with subpial hemorrhages and contribute to a better knowledge of this condition. Material and methods: Clinical records and magnetic resonance (MR) imaging data of all neonates with subpial hemorrhage followed at a pediatric hospit...
Preliminary virtual screening studies to identify grp78 inhibitors which may in...
Palmeira, A; Sousa, E; Köseler, A; Sabirli, R; Gören, T; Türkçüer, I; Kurt, Ö; Pinto, MM; Vasconcelos, MHSARS-CoV-2 Spike protein was predicted by molecular docking to bind the host cell surface GRP78, which was suggested as a putative good molecular target to inhibit Covid-19. We aimed to confirm that GRP78 gene expression was increased in blood of SARS-CoV-2 (+) versus SARS-CoV-2 (-) pneumonia patients. In addition, we aimed to identify drugs that could be repurposed to inhibit GRP78, thus with potential anti-SA...
Catechols from abietic acid
Gigante, B; Santos, C; Silva, AM; Curto, MJM; Nascimento, MSJ; Pinto, E; Pedro, M; Cerqueira, F; Pinto, MM; Duarte, MP; Laires, A; Rueff, JCatechols from abietic acid were prepared by a short and good yielding chemical process and further evaluated for several biological activities namely, antifungal, antitumoral, antimutagenic, antiviral, antiproliferative and inhibition of nitric oxide. Their properties were compared with those of carnosic acid (6), a naturally occurring catechol with an abietane skeleton and known to possess potent antioxidant ...