4 documents found, page 1 of 1
Xanthones for melanogenesis inhibition : Molecular docking and QSAR studies to ...
Rosa, Gonçalo P.; Palmeira, A.; Resende, Diana I. S. P.; Almeida, Isabel F.; Kane-Pagès, Aida; Barreto, Maria do Carmo; Sousa, E.; Pinto, Madalena M. M.The human skin is constantly exposed to external factors that affect its integrity, UV radiation being one of the main stress factors. The repeated exposure to this radiation leads to increased production of Reactive Oxygen Species (ROS) which activate a series of processes involved in photoaging. Excessive UV exposure also exacerbates melanin production leading to a variety of pigmentation disorders. Xanthones...
Semi-synthesis of small molecules of aminocarbazoles: tumor growth inhibition a...
Long, Solida; Loureiro, Joana B.; Carvalho, Carla; Gales, Luís; Saraiva, Lucília; Pinto, Madalena M. M.; Puthongking, Ploenthip; Sousa, EmíliaThe tumor suppressor p53 is inactivated by mutation in approximately 50% of human cancers. Small molecules that bind and stabilize those mutants may represent effective anticancer drugs. Herein, we report the tumor cell growth inhibitory activity of carbazole alkaloids and amino derivatives, as well as their potential activation of p53. Twelve aminocarbazole alkaloids were semi-synthesized from heptaphylline (<...
Efficacy, Stability, and Safety Evaluation of New Polyphenolic Xanthones Toward...
Resende, Diana I. S. P.; Almeida, Mariana C.; Maciel, Bruna; Carmo, Helena; Lobo, José Sousa; Dal Pozzo, Carlotta; Cravo, Sara M.; Rosa, Gonçalo P.Antioxidants have long been used in the cosmetic industry to prevent skin photoaging, which is mediated by oxidative stress, making the search for new antioxidant compounds highly desirable in this field. Naturally occurring xanthones are polyphenolic compounds that can be found in microorganisms, fungi, lichens, and some higher plants. This class of polyphenols has a privileged scaffold that grants them severa...
Yicathins B and C and analogues: total synthesis, lipophilicity and biological ...
Loureiro, Daniela R. P.; Magalhães, Álvaro F.; Soares, José X.; Pinto, Joana; Azevedo, Carlos M. G.; Vieira, Sara; Henriques, AnaNatural products had always be an important source of new hits and leads in drug discovery. The marine environment has been regarded as a significant souce of novel and exquisite bioactive compounds. Yicathins B and C are two marine derived xanthones that have shown antibacterial and antifungal activities. Herein, the total synthesis of these yicathins is reported for the first time as well as six novel analogu...