2 documents found, page 1 of 1
Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Ca...
Martins, Flávia; Oliveira, Rosa; Cavadas, Bruno; Pinto, Filipe; Cardoso, Ana Patrícia; Castro, Flávia; Sousa, Bárbara; Pinto, Marta LaranjeiroIn colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage-cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...
Decellularizing human colorectal cancer matrices as a 3D-organotypic model to e...
Pinto, Marta LaranjeiroDissertação de mestrado em Biologia Celular e Molecular, apresentada ao Departamento Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra.; Os tumores são microecossistemas complexos compostos por células tumorais, componentes da matriz extracelular (MEC) e outros tipos celulares. A interacção entre as células tumorais e os ambientes que as rodeia é crucial na progressão tumoral. Os...