23 documents found, page 1 of 3
Fabrication, electrochemical characterization, and In vivo validation of a flex...
Freitas, João R.; Rodrigues, José Artur Oliveira; Machado, João L.; Aguiar, Leandro Alvaro Alcantara; Rodrigues, Ana João; Oliveira, João F.The use of flexible neural probes for brain recordings presents several advantages compared to rigid neural probes. The main advantage is related to the reduction of damage to the neural tissue when using a flexible invasive neural probe. This work presents the fabrication, characterization, and in vivo validation of a flexible neural probe fabricated with photosensitive and low-temperature cured polyimide. The...
StressMatic: Bridging innovation and reliability in animal models of stress
Martins-Macedo, Joana; Gomes, Eduardo D.; Oliveira, João F.; Patrício, Patrícia; Pinto, Luísa; Gomes, EduardoPreclinical research involving animal models of stress exposure typically rely on traditional manual protocols, which are laborious and time-consuming and may compromise reproducibility and the effective translation of f indings into clinical applications. StressMatic is an automated stress exposure system (auCMS), designed to improve the standardization and reproducibility of stress-induction methodologies. Th...
Footwear segmentation and recommendation supported by deep learning: an explora...
Oliveira, João F.; Gomes, Rui; Gonzalez, Dibet; Sousa, Nuno; Shahrabadi, Somayeh; Guevara, Miguel; Ferreira, Maria Jose; Alves, Pedro; Peres, EmanuelThe management of an online footwear retail store-Also known as marketplace-usually involves activities that directly or indirectly end up to interface with customers, wherein communication efficiency and effectiveness is crucially relevant. Critical factors concerning entities developing remote business in these areas or similar include: (i) production of appealing catalogues and (ii) digital tools to shorten ...
Genetic ablation of inositol 1,4,5-Trisphosphate receptor type 2 (IP3R2) fails ...
Garcia, Daniela Raquel Cunha; Fernandes, Daniela Monteiro; Correia, Joana Sofia; Carvalho, Andreia Alexandra NevesSpinocerebellar ataxia type 3 (SCA3) is a rare neurodegenerative disease caused by an abnormal polyglutamine expansion within the ataxin-3 protein (ATXN3). This leads to neurodegeneration of specific brain and spinal cord regions, resulting in a progressive loss of motor function. Despite neuronal death, non-neuronal cells, including astrocytes, are also involved in SCA3 pathogenesis. Astrogliosis is a common p...
StressMatic: a novel automated system to induce depressive- and anxiety-like ph...
Martins-Macedo, Joana; Mateus-Pinheiro, António; Alves, Cátia; Veloso, Fernando José Silva; Gomes, Eduardo D.; Ribeiro, Inês; Correia, Joana S.Major depressive disorder (MDD) is a multidimensional psychiatric disorder that is estimated to affect around 350 million people worldwide. Generating valid and effective animal models of depression is critical and has been challenging for neuroscience researchers. For preclinical studies, models based on stress exposure, such as unpredictable chronic mild stress (uCMS), are amongst the most reliable and used, ...
Beyond new neurons in the adult hippocampus: imipramine acts as a pro-astroglio...
Machado-Santos, Ana R.; Loureiro-Campos, Eduardo; Patrício, Patrícia; Araújo, Bruna Alexandra Vale; Alves, Nuno Dinis; Mateus-Pinheiro, AntónioDepression is a prevalent, socially burdensome disease. Different studies have demonstrated the important role of astrocytes in the pathophysiology of depression as modulators of neurotransmission and neurovascular coupling. This is evidenced by astrocyte impairments observed in brains of depressed patients and the appearance of depressive-like behaviors upon astrocytic dysfunctions in animal models. However, l...
Low-cost silicon neural probe: fabrication, electrochemical characterization an...
Rodrigues, José Artur Oliveira; Pimenta, Sara; Pereira, José P.; Gomes, Nuno M.; Souto, Márcio R.; Fernandes, Helena C.; Caetano, InêsThis paper presents the fabrication of a silicon neural probe using low-cost microfabrication technologies, such as thin-films deposition, blade dicing, and photolithography. The metal stack that forms the 9 microelectrodes of 50 × 50 µm2 area, the tracks and the pads were made of Ti and Pt, while the passivation stack was SiO2 and Si3N4. The fabricated probe was characterized using electrochemical impedance sp...
Developments of a bim Add-on Tool for Deep Renovation of Buildings
Rodrigues, Eugénio; Fernandes, Marco S.; Gaspar, Adélio R.; Gomes, Álvaro; Oliveira, João F.; Mateus, Luís C.; Ferreira, Victor M.This paper presents the current state of development of a generation and performance evaluation tool to assist building practitioners in the early stages of deep renovation of buildings. This includes the tool workflow and its modules, such as the generative design method, the building performance evaluation mechanism, and the optimization procedure that improves the building geometry and construction system, a...
Region-specific control of microglia by adenosine A2A receptors: uncoupling anx...
Duarte, Joana Mendes; Gaspar, Rita; Caetano, Liliana; Patrício, Patrícia; Cunha, Carina Isabel Soares; Pinheiro, António Maria Restolho MateusEpidemiologic studies have provided compelling evidence that prenatal stress, through excessive maternal glucocorticoids exposure, is associated with psychiatric disorders later in life. We have recently reported that anxiety associated with prenatal exposure to dexamethasone (DEX, a synthetic glucocorticoid) correlates with a gender-specific remodeling of microglia in the medial prefrontal cortex (mPFC), a cor...
Functional Roles of Astrocyte Calcium Elevations: From Synapses to Behavior
Gomes, Sónia Isabel Nunes Guerra; Sousa, Nuno; Pinto, Luísa; Oliveira, João F.Astrocytes are fundamental players in the regulation of synaptic transmission and plasticity. They display unique morphological and phenotypical features that allow to monitor and to dynamically respond to changes. One of the hallmarks of the astrocytic response is the generation of calcium elevations, which further affect downstream cellular processes. Technical advances in the field have allowed to spatially ...