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Influence of the time of occlusion on the quantitative parameters obtained by m...

Pinto, PC; Rodrigues, LM

Understanding the human cutaneous barrier function is one of the main goals in the study of skin physiology. The plastic occlusion stress test (POST) is a well-known, dynamic approach for studying the barrier, evoking an over-stimulation of the cutaneous water assessed by the trans-epidermal water loss (TEWL) measurement. Rigorous data analysis is imperative, and the compartmental model proposed is particularly...


Exploring the influence of skin perfusion on transepidermal water loss

Rodrigues, LM; Pinto, PC; Magro, JM; Fernandes, M; Alves, J

Background: Eventual relationships between the vascular function and transepidermal water loss (TEWL), in vivo, have not been entirely explored. By promoting local perfusion alterations through a well-known challenge test, the 'tourniquet-cuff occlusion' manoeuvre, the present study searches for other dynamical factors influencing the cutaneous barrier, further exploring the applicability of these flow-related ...


Assessment of the performance of a new generation of tewameters

Rosado, C; Goncalves, C; Pinto, PC; Rodrigues, LM


Development of a new methodology to assess cutaneous hydration

Rosado, C; Rei, F; Rolim, L; Pinto, PC; Rodrigues, LM


In vivo evaluation of photoprotective activity of solid lipid nanoparticles for...

Toscano, C; Farinha, A; Pinto, PC; Magro, JM; Rei, F; Almeida, AJ; Rodrigues, LM


Quantification of skin barrier recovery by compartmental modelling of TEWL in b...

Pinto, PC; Magro, JM; Goncalves, C; Rei, F; Rolim, I; Furtado, N; Almeida, MA; Rodrigues, LM


Quantitative description of human skin water dynamics by a disposition-decompos...

Rodrigues, LM; Pinto, PC; Pereira, LM

Background: In vivo water assessment would greatly benefit from a dynamical approach since the evaluation of common related variables such as trans -epidermal water loss or "capacitance" measurements is always limited to instantaneous data. Mathematical modelling is still an attractive alternative already attempted with bi-exponential empirical models. A classical two-compartment interpretation of such models r...


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