Understanding the human cutaneous barrier function is one of the main goals in the study of skin physiology. The plastic occlusion stress test (POST) is a well-known, dynamic approach for studying the barrier, evoking an over-stimulation of the cutaneous water assessed by the trans-epidermal water loss (TEWL) measurement. Rigorous data analysis is imperative, and the compartmental model proposed is particularly...
Background: Eventual relationships between the vascular function and transepidermal water loss (TEWL), in vivo, have not been entirely explored. By promoting local perfusion alterations through a well-known challenge test, the 'tourniquet-cuff occlusion' manoeuvre, the present study searches for other dynamical factors influencing the cutaneous barrier, further exploring the applicability of these flow-related ...
Background: In vivo water assessment would greatly benefit from a dynamical approach since the evaluation of common related variables such as trans -epidermal water loss or "capacitance" measurements is always limited to instantaneous data. Mathematical modelling is still an attractive alternative already attempted with bi-exponential empirical models. A classical two-compartment interpretation of such models r...