3 documents found, page 1 of 1
Glutaraldehyde-crosslinking chitosan scaffolds reinforced with calcium phosphat...
Pinto, Rosana V.; Gomes, Pedro S.; Fernandes, Maria H.; Costa, Maria E.V.; Almeida, Maria M.The clinical demand for bone scaffolds as an alternative strategy for bone grafting has increased exponentially and, up to date, numerous formulations have been proposed to regenerate the bone tissue. However, most of these structures lack at least one of the fundamental/ideal properties of these materials (e.g., mechanical resistance, interconnected porosity, bioactivity, biodegradability, etc.). In this work,...
New generation of nitric oxide-releasing porous materials: assessment of their ...
Pinto, Rosana V.; Fernandes, Ana C.; Antunes, Fernando; Lin, Zhi; Rocha, João; Pires, João; Pinto, Moisés L.Nitric oxide (NO) presents innumerable biological roles, and its exogenous supplementation for therapeutic purposes has become a necessity. Some nanoporous materials proved to be potential vehicles for NO with high storage capacity. However, there is still a lack of information about their efficiency to release controlled NO and if they are biocompatible and biologically stable. In this work, we address this kn...
Novel doped calcium phosphate-PMMA bone cement composites as levofloxacin deliv...
Matos, Ana C.; Marques, Catarina F.; Pinto, Rosana V.; Ribeiro, Isabel A. C.; Goncalves, Ldia M.; Vaz, Mario A.; Ferreira, J. M. F.; Almeida, Antonio J.Antibiotic-loaded acrylic bone cements (ALABCs) are well-established and cost-effective materials to control the occurrence of bone and joint infections. However, the inexistence of alternative antibiotics other than those already commercially available and the poor ability to bind to bone tissue hampering its biological function are still major drawbacks of ALABCs clinical application. The concept of this rese...