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O sabor amargo de fármacos constitui uma barreira à adesão terapêutica em pediatria. Existem disponíveis várias estratégias para mascarar o amargor, mas a maioria é de difícil implementação na Farmácia Hospitalar (FH). Desenvolvimento de um veículo para administração oral para uso pediátrico, de composição simples e de fácil preparação, com o objetivo de mascarar o sabor amargo de um fármaco modelo com elevado ...
A facilidade de administração e a possibilidade de ajuste de dose das formas farmacêuticas líquidas para administração oral, reforçam a sua grande utilidade na população pediátrica
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No abstract available.
Amyotrophic lateral sclerosis (ALS) is a rapidly progressive condition characterized by upper and lower motor neuron loss. Over the last decades, epidemiological and clinical data from European, North America and high-incoming Asia-Pacific countries has been extensively collected and analyzed, improving the knowledge regarding ALS. However, ALS had not been reported in Africans until 1955. Even today, data from...
Background and purpose: Respiratory insufficiency and its complications are the main cause of death in amyotrophic lateral sclerosis (ALS). Respiratory symptoms are scored in questions Q10 (dyspnoea) and Q11 (orthopnoea) of the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R). The association of respiratory test alterations with respiratory symptoms is unclear. Methods: Patients with ALS...
Objectives: High-intensity physical activity and sports prone to repetitive injuries of the cervical spine and head (when associated with vigorous practice) have been suggested as possible risk factors for amyotrophic lateral sclerosis (ALS). Our objective was to evaluate the relationship between the practice of contact sports (boxing, hockey, football, rugby) and ALS. Methods: The study included 2247 individua...
Designing oral formulations for children is very challenging, especially considering their peculiarities and preferences. The choice of excipients, dosing volume and palatability are key issues of pediatric oral liquid medicines. The purpose of the present study is to develop an oral pediatric solution of a model bitter drug (ranitidine) following a patient centric design process which includes the definition o...