12 documents found, page 1 of 2

A level-shift carrier PWM modulation technique and predictive current control o...

The integration of renewable energy sources into the electrical power grid is a crucial aspect for achieving sustainable development and reducing en-vironmental impacts. This paper explores the implementation of a three-phase Neutral Point Clamped (NPC) DC-AC converter with level-shift carrier PWM modulation technique and predictive current control to facilitate the grid inter-connection of renewable energy sys...

Virtual environment for communication skills training in health: the case of ph...

This paper describes a Virtual Reality prototype for technical and communication skills training of Pharmaceutical Sciences students. In a simulated situation, a virtual human plays the role of a patient requiring the assistance of a professional in a pharmacy, communicating via textual messages. The student communicates with this virtual character by choosing options in the interface of the application. This i...

Virtual humans playing the role of patients in self‐medication consultations : ...

Tau protein is essential for stress-induced brain pathology

Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in association with neurostructural adaptations. Chronic stress was previously shown to trigger Alzheimer's-like neuropathology, which is characterized by Tau hyper-phosphorylation and missorting into dendritic spines followed by memory deficits. Here, we demonstrate that stress-driven hippocampal deficits in wild-type mic...

Differential impact of chronic stress along the hippocampal dorsal–ventral axis

Stress impacts differently in distinct brain regions. However, so far few studies have focused on the differential responses triggered by stressful stimuli on the intrinsic functional heterogeneity of the hippocampal axis. In this study, we assessed the functional and structural alterations caused by exposure to a chronic unpredictable stress (CUS) paradigm on the dorsal-ventral axis of the hippocampus. The mor...

Selective impact of Tau loss on nociceptive primary afferents and pain sensation

Tau protein hyperphosphorylation and consequent malfunction are hallmarks of Alzheimer's disease pathology; importantly, pain perception is diminished in these patients. In physiological conditions, Tau contributes to cytoskeletal dynamics and in this way, influences a number of cellular mechanisms including axonal trafficking, myelination and synaptic plasticity, processes that are also implicated in pain perc...

Ambiente virtual para treino de competências de comunicação na área da saúde : ...

Este artigo descreve um protótipo de Realidade Virtual destinado ao treino de competências técnicas e de comunicação dos estudantes de Ciências Farmacêuticas. Numa situação simulada, um humano virtual desempenha o papel de um paciente/doente que requer o apoio de um profissional numa farmácia, comunicando com este através de mensagens de texto. O estudante comunica com este personagem virtual escolhendo opções ...

Spintronic devices for biomedical applications

Spintronic devices have been proposed over the past decade for various biomedical applications. These include static or dynamic biomolecular recognition platforms ( DNA-cDNA, antibody-antigen, phage-bacteria, ), cytometer and cell separation devices and lateral bio assay platforms , microelectrode based devices for neuroelectronic applications, and hybrid sensor arrays for imaging applications [1]. The biomolec...

Integration of TMR sensors in silicon microneedles for magnetic measurements of...

In this work an alternative neuroscience tool for electromagnetic measurements of neurons at the level of individual cells is developed. To perform such measurements we propose the integration of an array of magnetoresistive sensors on micro-machined Si probes capable of being inserted within the brain without further damage. Si-etch based micromachining process for neural probes is demonstrated in the manufact...

Lipocalin-2 is involved in emotional behaviors and cognitive function

Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display anxious and depressive-like behaviors, as well as cognitive impairment in ...