3 documents found, page 1 of 1
Regulation of Nociceptive Glutamatergic Signaling by Presynaptic Kv3.4 Channels...
Muqeem, Tanziyah; Ghosh, Biswarup; Pinto, Vítor Manuel Silva; Lepore, Angelo C.; Covarrubias, ManuelPresynaptic voltage-gated K+ (Kv) channels in dorsal root ganglion (DRG) neurons are thought to regulate nociceptive synaptic transmission in the spinal dorsal horn. However, the Kv channel subtypes responsible for this critical role have not been identified. The Kv3.4 channel is particularly important because it is robustly expressed in DRG nociceptors, where it regulates action potential (AP) duration. Furthe...
Tau mislocation in glucocorticoid-triggered hippocampal pathology
Pinheiro, Sara; Silva, Joana; Mota, Cristina de Fátima Sousa da; Silva, João Luís Vaz Lima da; Veloso, Ana Cristina Costa; Pinto, Vítor Manuel SilvaThe exposure to high glucocorticoids (GC) triggers neuronal atrophy and cognitive deficits, but the exact cellular mechanisms underlying the GC-associated dendritic remodeling and spine loss are still poorly understood. Previous studies have implicated sustained GC elevations in neurodegenerative mechanisms through GC-evoked hyperphosphorylation of the cytoskeletal protein Tau while Tau mislocation has recently...
Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits a...
Lopes, Sofia Oliveira; Lopes, André Teixeira; Pinto, Vítor Manuel Silva; Guimarães, Marco Rafael; Sardinha, Vanessa Alexandra Morais; Silva, Sara DuarteDementia is the cardinal feature of Alzheimer's disease (AD), yet the clinical symptoms of this disorder also include a marked loss of motor function. Tau abnormal hyperphosphorylation and malfunction are well-established key events in AD neuropathology but the impact of the loss of normal Tau function in neuronal degeneration and subsequent behavioral deficits is still debated. While Tau reduction has been inc...