7 documents found, page 1 of 1
Reply to Letter to the Editor Concerning “HIPTCN: Prospective Observational Stu...
Duarte-Batista, Pedro; Hipólito Reis, José; Silva, João; Sequeira Lemos, Samuel; Cubas Farinha, Nuno; Marques, Renata; Páscoa Pinheiro, João; Tuna, RuiN/a.; N/a.
HIPTCN: Prospective Observational Study of Hypocoagulated Head Trauma Patients ...
Duarte-Batista, Pedro; Farinha, Nuno Cubas; Marques, Renata; Pinheiro, João Páscoa; Silva, João; Tuna, Rui; Reis, José Hipólito; Antunes, CristianoIntroduction: Our national protocol for traumatic brain injury dictates that hypocoagulated patients with mild trauma and initial tomography scan with no intracranial traumatic changes must be hospitalized for 24 hours and do a post-surveillance tomography scan. The main goal of this study was to evaluate the clinical relevance of these measures.Material and Methods: A prospective observational study was undert...
HIPTCN: Prospective Observational Study of Hypocoagulated Head Trauma Patients ...
Duarte-Batista, Pedro; Farinha, Nuno Cubas; Marques, Renata; Pinheiro, João Páscoa; Silva, João; Tuna, Rui; Reis, José Hipólito; Antunes, CristianoIntroduction: Our national protocol for traumatic brain injury dictates that hypocoagulated patients with mild trauma and initial tomography scan with no intracranial traumatic changes must be hospitalized for 24 hours and do a post-surveillance tomography scan. The main goal of this study was to evaluate the clinical relevance of these measures. Material and methods: A prospective observational study was under...
TERT promoter mutations in pancreatic endocrine tumours are rare and mainly fou...
Vinagre, João; Nabais, Joana; Pinheiro, Jorge; Batista, Rui; Oliveira, Rui Caetano; Gonçalves, António Pedro; Pestana, Ana; Reis, MartaOne of the hallmarks of cancer is its unlimited replicative potential that needs a compensatory mechanism for the consequential telomere erosion. Telomerase promoter (TERTp) mutations were recently reported as a novel mechanism for telomerase re-activation/expression in order to maintain telomere length. Pancreatic endocrine tumors (PETs) were so far recognized to rely mainly on the alternative lengthening of t...
Telomerase promoter mutations in cancer: an emerging molecular biomarker?
Vinagre, João; Pinto, Vasco; Celestino, Ricardo; Reis, Marta; Populo, H; Boaventura, Paula; Melo, Miguel; Catarino, T.; Lima, Jorge; Lopes, José ManuelCell immortalization has been considered for a long time as a classic hallmark of cancer cells. Besides telomerase reactivation, such immortalization could be due to telomere maintenance through the “alternative mechanism of telomere lengthening” (ALT) but the mechanisms underlying both forms of reactivation remained elusive. Mutations in the coding region of telomerase gene are very rare in the cancer setting,...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...
Frequency of TERT promoter mutations in human cancers
Vinagre, João; Almeida, Ana; Pópulo, Helena; Batista, Rui; Lyra, Joana; Pinto, Vasco; Coelho, Ricardo; Celestino, Ricardo; Prazeres, Hugo; Lima, LuísReactivation of telomerase has been implicated in human tumorigenesis, but the underlying mechanisms remain poorly understood. Here we report the presence of recurrent somatic mutations in the TERT promoter in cancers of the central nervous system (43%), bladder (59%), thyroid (follicular cell-derived, 10%) and skin (melanoma, 29%). In thyroid cancers, the presence of TERT promoter mutations (when occurring tog...