2 documents found, page 1 of 1
Melittin induces in vitro death of Leishmania (Leishmania) infantum by triggeri...
Pereira,Andreia Vieira; Barros,Gustavo de; Pinto,Erika Gracielle; Tempone,Andre Gustavo; Orsi,Ricardo de Oliveira; Santos,Lucilene Delazari dosAbstract Background Apis mellifera venom, which has already been recommended as an alternative anti-inflammatory treatment, may be also considered an important source of candidate molecules for biotechnological and biomedical uses, such as the treatment of parasitic diseases. Methods Africanized honeybee venom from Apis mellifera was fractionated by RP-C18-HPLC and the obtained melittin was incubated with proma...
Antileishmanial and antitrypanosomal activity of the cutaneous secretion of Sip...
Pinto,Erika Gracielle; Antoniazzi,Marta Maria; Jared,Carlos; Tempone,and Andre GustavoBackground Among the tropical parasitic diseases, those caused by protozoans are considered a challenge to public health, being represented by leishmaniasis and Chagas disease. In view of the low effectiveness and toxicity of the current therapy, animal venoms such as amphibian secretions have been used as a promising source of new drug prototypes. The present work aimed to achieve bioguided fractionation of me...