6 documents found, page 1 of 1
Anti-Inflammatory Meroterpenoids of Cordia glazioviana (Boraginaceae)
Silva,Ana Karine O.; Pinto,Francisco C. L.; Canuto,Kirley M.; Braz-Filho,Raimundo; Silva,Rose Anny C.; Santos,Flávia A.; Monteiro,Norberto K. V.The phytochemical reinvestigation from the heartwood of the extracts of Cordia glazioviana led to the isolation of four still undescribed hydroquinones derivatives designated as cordiaquinol D (1), cordiaquinol E (2), (10R)-10,11-dihydrofuran-1,4-dihydroxy-globiferin (3) and 2-[(1’E,6’E)-3’,8’- dihydroxy-3’,7’-dimethylocta-1’,6’-dienyl]-benzene-1,4-diol (4), along with the naphthoquinone 6-[(2’R)-2’-hydroxy-3’,...
Dextrorotatory Chromomycins from the Marine Streptomyces sp. Associated to Paly...
Pinto,Francisco C. L.; Silveira,Edilberto R.; Vasconcelos,Ana Caroline L.; Florêncio,Katharine G. D.; Oliveira,Francisca A. S.; Sahm,Bianca B.A Streptomyces sp. (BRA-384) was selected among nine strains of bacteria isolated from the zoanthids Palythoa caribaeorum due to the high cytotoxic activity presented by its EtOAc extract (inhibitory concentration mean (IC50) of 2 ng mL-1) against colon cancer cell line. From the EtOAc extract of BRA-384 three new chemical entities (A6, A7 and A8) and one dextrorotatory chromomycin (A5), a promising class of an...
New Antiproliferative Polyunsaturated Epoxy-Heneicosane Derivatives Isolated fr...
Ávila,Fábio N.; Pinto,Francisco C. L.; Carneiro,Pedro B. M.; Ferreira,Kayanny Q.; Wilke,Diego V.; Nogueira,Nádia A. P.; Silveira,Edilberto R.Two new polyunsaturated 3,4-epoxy-heneicosane derivatives named as epoxy-lobophorene A and epoxy-lobophorene B were isolated from the brown alga Lobophora variegata, in addition to nine known compounds. The structures of the new compounds were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). The isolated compounds were submitted ...
Withanolides from Leaves of Nicandra physalodes
Carrero,Diego A. S.; Batista,Pedro H. J.; Souza,Luciana G. S.; Pinto,Francisco C. L.; Vasconcelos,Mayron A. de; Teixeira,Edson H.; Canuto,Kirley M.Five new withanolides, designated as 15-oxo-nicaphysalin B, 6β,7α-dihydroxynicandrenone 10, 24α,25β-dihydroxy-nicandrenone-2 and a mixture of the epimers 17-(1α/1β-methylpropanone)-nicandrenone, in addition to six known others, were isolated from the leaf acetone extract from Nicandra physalodes. The complete structures of the five new withanolides, particularly their relative stereochemistries, were establishe...
Steroids from the Brazilian Zoanthids Palythoa caribaeorum and Palythoa variabilis
Pinto,Francisco C. L.; Almeida,José Gustavo L.; Silveira,Edilberto R.; Costa,Arinice M.; Guimarães,Larissa A.; Wilke,Diego V.; Costa-Lotufo,Letícia V.Two unreported ergostane-type sterols 24(R)-7α-hydroperoxy-ergost-5-en-3β-ol and 6β-carboxyl-24(R)-(8→6)-abeo-ergostan-3β,5β-diol, along with seven known ones were isolated from the hexane and alcohol extracts from the zoanthids Palythoa caribaeorum and Palythoa variabilis. The structures of the new compounds were determined using spectroscopic techniques, including 1D and 2D nuclear magnetic resonance (NMR), h...
Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd
Ávila,Fábio N.; Pinto,Francisco C. L.; Sousa,Thiciana S.; Torres,Maria Conceição M.; Costa-Lotufo,Leticia V.; Rocha,Danilo D.; Vasconcelos,Mayron A. deFive new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of a...