8 documents found, page 1 of 1

"Mannose glycans as key players in trained immunity: A novel anti-tumoral catal...

Cell wall glycans isolated from microorganisms are long known to provoke strong immune responses piloted by innate immune cell populations, including monocytes, in the context of Trained Immunity (TI). However, the contribution of yeast-derived mannan in the reprogramming of monocytes remains ill-defined. Here, we demonstrated that TI is often accompanied by an altered gene expression profile of selected glycan...

Investigação Clínica da Iniciativa do Investigador em Portugal: Identificação d...

Emerging lab-on-a-chip approaches for liquid biopsy in lung cancer: Status in c...

Despite the intensive efforts dedicated to cancer diagnosis and treatment, lung cancer (LCa) remains the leading cause of cancer-related mortality, worldwide. The poor survival rate among lung cancer patients commonly results from diagnosis at late-stage, limitations in characterizing tumor heterogeneity and the lack of non-invasive tools for detection of residual disease and early recurrence. Henceforth, resea...

Urinary extracellular vesicles as potential biomarkers for urologic cancers: An...

Urologic cancers are a heterogeneous group of tumors, some of which have poor progno-sis. This is partly due to the unavailability of specific and sensitive diagnostic techniques and monitoring tests, ideally non-or minimally invasive. Hence, liquid biopsies are promising tools that have been gaining significant attention over the last decade. Among the different classes of bi-omarkers that can be isolated from...

Comparison and Optimization of DNA Extraction Methods from Cervical Cells Colle...

Cervical cancer is the ninth leading cancer in women in Portugal. Cervical cancer screening methods have changed since the implementation of the cytology-based test developed by George Papanicolaou until the human papillomavirus-based screening. Nowadays, new biomarkers like deoxyribonucleic acid (DNA) methylation has been proposed as potential triage method of samples testing positive for human papillomavirus ...

The impact of [c16pyr][amp] on the aggressiveness in breast and prostate cancer...

Breast (BrCa) and prostate (PCa) cancers are the most common malignancies in women and men, respectively. The available therapeutic options for these tumors are still not curative and have severe side effects. Therefore, there is an urgent need for more effective antineoplastic agents. Herein, BrCa, PCa, and benign cell lines were treated with two ionic liquids and two quinoxalines and functional experiments we...

Profiling DNA methylation based on next-generation sequencing approaches: New i...

DNA methylation is an epigenetic modification that plays a pivotal role in regulating gene expression and, consequently, influences a wide variety of biological processes and diseases. The advances in next-generation sequencing technologies allow for genome-wide profiling of methyl marks both at a single-nucleotide and at a single-cell resolution. These profiling approaches vary in many aspects, such as DNA inp...

MiR-193b promoter methylation accurately detects prostate cancer in urine sedim...

Background: Contemporary challenges of prostate cancer (PCa) include overdiagnosis and overtreatment, entailing the need for novel clinical tools to improve risk stratification and therapy selection. PCa diagnosis and prognostication might be perfected using epigenetic biomarkers, among which aberrant DNA methylation of microRNA promoters has not been systematically explored. Herein, we identified aberrantly me...