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Fecal Dipeptidyl Peptidase-4: An Emergent Biomarker in Inflammatory Bowel Disease

Pinto-Lopes, P; Melo, F; Afonso, J; Pinto-Lopes, R; Rocha, C; Melo, D; Macedo, G; Dias, CC; Carneiro, F; Magro, F

INTRODUCTION: Dipeptidyl peptidase-4 (DPP-4) is a membrane-bound glycoprotein that acts as a receptor but also exists in a soluble form. It has been recognized as a mediator of inflammation and considered a biomarker in inflammatory bowel disease (IBD). METHODS: We evaluated a prospectively recruited cohort, consisting of 101 patients with IBD, using validated clinical indexes; 22 patients with ulcerative colit...


Trends in respiratory management and morbidities of very preterm or very low bi...

Pinto-Lopes, R; Abreu-Pereira, S; Rocha, G; Flor-de-Lima, F; Rodrigues, C; Silva, G; Guedes, MB; Guimarães, H

Summary: Considerable progress has been made regarding children’s morbidity and mortality. Nonetheless, recent developments have been insufficient to meet set targets. This study aims to evaluate trends and outcomes in respiratory management following a 14-year collaboration with the Vermont Oxford Network (VON). Methods: Data were collected prospectively at a Level III NICU in the North of Portugal and submitt...


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