25 documents found, page 1 of 3
Anti-inflammatory effect of Pterospartum tridentatum leaf extract in acute and ...
Laranjeira, Inês Martins; Gonçalves, João N. D.; Gonçalves, Cátia; Silva, Marlene; Mouta, Nuno; Dias, Alberto C. P.; Pinto-Ribeiro, FilipaPterospartum tridendatum is an important source of active compounds with anti-inflammatory properties. The ability of P. tridentatum leaves methanolic extract in preventing/reversing inflammation was studied in adult rats using a model of experimental osteoarthritis (OA) and ear edema. Control animals (SHAM) were administered phosphate buffer solution (PBS), while OA animals received either P. tridentatum 100 m...
Prognostic value of Monocarboxylate Transporter 1 overexpression in cancer: a s...
Silva, Ana; Cerqueira, Mónica Costa; Rosa, Beatriz; Sobral, Catarina; Pinto-Ribeiro, Filipa; Costa, Marta Sílvia Freitas; Baltazar, FátimaEnergy production by cancer is driven by accelerated glycolysis, independently of oxygen levels, which results in increased lactate production. Lactate is shuttled to and from cancer cells via monocarboxylate transporters (MCTs). MCT1 works both as an importer and an extruder of lactate, being widely studied in recent years and generally associated with a cancer aggressiveness phenotype. The aim of this systema...
Effects of intermittent fasting on regulation of metabolic homeostasis: a syste...
Silva, Ana Inês; Direito, Manuel; Pinto-Ribeiro, Filipa; Ludovico, Paula; Marques, Maria Belém Sousa SampaioIntermittent fasting (IF) is an emerging dietetic intervention that has been associated with improved metabolic parameters. Nowadays, the most common IF protocols are Alternate-Day Fasting (ADF) and Time-Restricted Fasting (TRF), but in this review and meta-analysis we have also considered Religious Fasting (RF), which is similar to TRF but against the circadian rhythm. The available studies usually include the...
Comparative neurotoxicity of dietary methylmercury and waterborne inorganic mer...
Carvalho, Patrícia S.; Fonseca-Rodrigues, Diana; Pacheco, Mário; Almeida, Armando; Pinto-Ribeiro, Filipa; Pereira, PatríciaThis work investigated the effects of inorganic mercury (iHg) and methylmercury (MeHg) on the fish optic tectum morphology, viz. in relation to: i) vulnerability of specific optic tectum layers; ii) preferential targeting of Hg forms to neurons or glial cells; iii) comparative toxicity of iHg and MeHg in this brain area that is in the maintenance of several fish behaviors. Two experiments exposing juvenile whit...
A new gal in town: a systematic review of the role of galanin and its receptors...
Rodrigues, Diana Marina Fonseca; Almeida, Armando; Pinto-Ribeiro, FilipaGalanin is a neuropeptide expressed in a small percentage of sensory neurons of the dorsal root ganglia and the superficial lamina of the dorsal horn of the spinal cord. In this work, we systematically reviewed the literature regarding the role of galanin and its receptors in nociception at the spinal and supraspinal levels, as well as in chronic pain conditions. The literature search was performed in PubMed, W...
An insight on the biomedical potential of portuguese propolis from Gerês
Araújo, Carina; Oliveira, Rafaela Dias; Pinto-Ribeiro, Filipa; Almeida Aguiar, CristinaOsteoarthritis (OA), a progressive degenerative disease of weight-bearing joints, is the second leading cause of disability in the world. Despite all the advances and research over the last years, none of the proposed strategies has been effective in generating functional and long-lasting tissue. Due to the high prevalence of OA and the urgent need for an effective and successful treatment, interest in natural ...
Management of COVID-19 Patients in Continuous Care Units: A Palliative Care Per...
Ribeiro, João; Pinto-Ribeiro, Filipa; Nunes, RuiN/a.; N/a.
In vivo anticancer activity of AZD3965: a systematic review
Silva, Ana; Antunes, Beatriz; Batista, Alberta; Pinto-Ribeiro, Filipa; Baltazar, Fátima; Afonso, Julieta Alexandra PereiraProliferating cancer cells have high energy demands, which is mainly obtained through glycolysis. The transmembrane trafficking of lactate, a major metabolite produced by glycolytic cancer cells, relies on monocarboxylate transporters (MCTs). MCT1 optimally imports lactate, although it can work bidirectionally, and its activity has been linked to cancer aggressiveness and poor outcomes. AZD3965, a specific MCT1...
Modulating inflammation through the neutralization of Interleukin-6 and tumor n...
Lima, Ana Cláudia Fernandes; Amorim, Diana Alexandra Silva; Laranjeira, Inês; Almeida, Armando; Reis, R. L.; Ferreira, Helena Susana Costa MachadoBiological agents that neutralize the activity of pro-inflammatory cytokines are revolutionizing the treatment of inflammatory conditions. However, the antibodies (Abs) short half-life and off-target distribution critically limit their efficacy and safety. Therefore, this work proposes the immobilization of anti-TNF-α and anti-IL-6 Abs at the surface of polymeric nanoparticles (NPs) in order to extend and incr...
A biocompatible and injectable hydrogel to boost the efficacy of stem cells in ...
Ferreira, Helena Susana Costa Machado; Amorim, Diana; Lima, Ana Cláudia Fernandes; Pirraco, Rogério P.; Pinto, Ana Rita Costa; Almeida, RuiAims: Stem cell therapies emerged as treatment modalities with potential to cure neurodegenerative diseases (NDs). However, despite high expectations, their clinical use is still limited. Critical issues in treatment outcomes may be related to stem cells formulation and administration route. We develop a hydrogel as a cell carrier, consisting of compounds (phospholipids and hyaluronic acid-HA) naturally present...