2 documents found, page 1 of 1
Pontastacus leptodactylus (Eschscholtz, 1823) and Faxonius limosus (Rafinesque,...
Nuc, Zofia; Brusotti, Gloria; Catenacci, Laura; Grenha, Ana; Pontes, Jorge Filipe; Pinto-da-Silva, Joana; Rosa Da Costa, Ana; Moro, PaolaThe growing demand for chitin and chitosan makes it necessary to look for new sources of these polymers and to develop more environmentally friendly methods for their isolation. The subjects of the current study were chitin and chitosan extracted from shells of two crayfish species: <i>P. leptodactylus</i> and <i>F. limosus</i>. The obtained polymers were characterized by physicochemical properties (molecular w...
The stress granule protein G3BP1 alleviates spinocerebellar ataxia-associated d...
Koppenol, Rebekah; Conceição, André; Afonso, Inês T.; Afonso-Reis, Ricardo; Costa, Rafael G; Tomé, Sandra; Teixeira, Diogo; Pinto-da-Silva, JoanaKoppenol et al. show that overexpression of G3BP1 in cell models of SCA2 and SCA3 leads to a reduction in ataxin-2 and ataxin-3 aggregation. G3BP1 lentiviral delivery reduces motor deficits and neuropathology in preclinical models, suggesting that G3BP1 may be a potential therapeutic target for polyQ disorders. Polyglutamine diseases are a group of neurodegenerative disorders caused by an abnormal expansion of ...