46 documents found, page 1 of 5
Towards a perception-based understanding of tyre/road noise
Barros, A.; Vuye, C.; Freitas, E. F.; Pereira, F.; Sousa, E.Environmental noise, and mostly road traffic noise, is a major environmental risk factor to human health. Strategies concerning noise abatement have been focusing on reducing objective noise levels. However, previous research has proven that other characteristics of noise, such as spectral content and temporal evolution, better explain how people perceive the acoustic environment. These characteristics can be q...
The ocean as a source of new anti-inflammatory and anti-pruritic molecules
Martins , M. S.; Long , S.; Pinto , M. M. M.; Almeida , I. F.; Cruz , M. T.; Sousa, E.Background: Pruritus, the most common symptom of skin diseases, is considered a chronic condition when experienced for more than six weeks. Although the etiology of the symptom remains elusive, chronic pruritus has been associated with neurokinin 1 receptor (NK1R) and its agonist substance P [1]. Since pruritus and inflammation often go together, the development of compounds with dual activity, specifically ant...
In silico study of (thio)xanthones-mediated P-glycoprotein activation
Veiga-Matos, J.; dos Santos, D. J. V. A.; Sousa, E.; Prieto Vicente, M.; Remião, F.; Silva, R.Background: P-glycoprotein (P-gp) is an efflux transporter located at the apical membrane of important barrier tissues, playing a crucial role in the detoxification of endobiotics and xenobiotics [1]. (Thio)xanthonic derivatives have been shown to be able of activating P-gp without increasing its expression, promoting an immediate increase in the amount of transported substrates. Thus, P-gp activation limits th...
Guia de boas práticas para a intervenção com pessoas LGBTI vítimas de violência...
Neves, Sofia; Ferreira, Mafalda; Topa, Joana; Borges, Janete S.; Vieira, Cristina Pereira; Allen, Paula; Sousa, E.; Costa, Rodrigo; Rocha, HelenaGuia de Boas Práticas para a Intervenção com Pessoas LGBTI Vítimas de Violência Doméstica.
Xanthones for melanogenesis inhibition : Molecular docking and QSAR studies to ...
Rosa, Gonçalo P.; Palmeira, A.; Resende, Diana I. S. P.; Almeida, Isabel F.; Kane-Pagès, Aida; Barreto, Maria do Carmo; Sousa, E.; Pinto, Madalena M. M.The human skin is constantly exposed to external factors that affect its integrity, UV radiation being one of the main stress factors. The repeated exposure to this radiation leads to increased production of Reactive Oxygen Species (ROS) which activate a series of processes involved in photoaging. Excessive UV exposure also exacerbates melanin production leading to a variety of pigmentation disorders. Xanthones...
Impact of Increasing Electric Vehicles Demand on the Distribution Network: A Po...
Nogueira, Teresa; Sousa, E.; Alves, Gustavo R.In the coming years, we will witness a change in the current car fleet sales, from traditional fuel engines towards electrical vehicles (EVs), particularly passenger light-duty vehicles. They plug into the grid and store the electricity in rechargeable batteries; therefore, the widespread adoption of EVs will bring many challenges for the distribution network. Forecasting the impact of EVs on distribution netwo...
Targeting antimicrobial drug resistance with marine natural products
Barbosa, F.; Pinto, E.; Kijjoa, A.; Pinto, M.; Sousa, E.The rise and spread of antimicrobial resistance represents one of the most pressing health issues of today. Antimicrobial resistance in micro-organisms can arise due to a multiplicity of factors, including perme- ability changes in the cell membrane, increase of drug efflux pumps, enzymatic modification or inacti- vation of the antibiotic, target site modification, alternative metabolic pathways and biofilm for...
Structure-antifouling activity relationship and molecular targets of bio-inspir...
Almeida, J.R.; Palmeira, A.; Campos, A.; Cunha, I.; Freitas, M.; Felpeto, A.B.; Turkina, M.V.; Vasconcelos, V.; Pinto, M.; Correia-Da-silva, M.The development of alternative ecological and effective antifouling technologies is still challenging. Synthesis of nature-inspired compounds has been exploited, given the potential to assure commercial supplies of potential ecofriendly antifouling agents. In this direction, the antifouling activity of a series of nineteen synthetic small molecules, with chemical similarities with natural products, were exploit...
One step forward towards the development of eco-friendly antifouling coatings: ...
Vilas-Boas, C.; Carvalhal, F.; Pereira, B.; Carvalho, S; Sousa, E.; Pinto, M.M.M.; Calhorda, M.J.; Vasconcelos, V.; Almeida, J.R.; Silva, E.R.Marine biofouling represents a global economic and ecological challenge and few eco-friendly antifouling agents are available. The aim of this work was to establish the proof of concept that a recently synthesized nature-inspired compound (gallic acid persulfate, GAP) can act as an eco-friendly and effective antifoulant when immobilized in coatings through a non-release strategy, promoting a long-lasting antifo...
Overcoming environmental problems of biocides: Synthetic bile acid derivatives ...
Neves, A.R.; Almeida, J.R.; Carvalhal, F.; Câmara, A.; Pereira, S.; Antunes, J.; Vasconcelos, V.; Pinto, M.; Silva, E.R.; Sousa, E.Marine biofouling represents a global economic and ecological challenge. Some marine organisms produce bioactive metabolites, such as steroids, that inhibit the settlement and growth of fouling organisms. The aim of this work was to explore bile acids as a new scaffold with antifouling (AF) activity by using chemical synthesis to produce a series of bile acid derivatives with optimized AF performance and unders...